Highlights   :         GPCR           Brain tumors           Brain hemorrhage

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Assistant Professor-Neurosciences-Rouen Normandie

  Job profile




  Team video link                                                                                  full page Group picture

  Publications      Grants and networks       Collaborations      News      Key events

Team leader: Dr Hélène Castel
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• General research interest

Vasoactive peptides and neurovascular unit: potential implication in reactive astrogliosis and in post-hemorragic ischemia - Impact of chemotherapeutics and targeted therapies on cognitive functions in animal models - Interactions glia-endothelium in the mechanisms of migration/invasion of glial tumors: structure-activity of G protein-coupled receptors and signaling pathways.

         • Cancer and Cognition platform  

   Web site : http://www.canceretcognition.fr - http//www.cancerandcognition.com
Expertises of the team : Preclinical expertise and biomarkers

http://www.canceretcognition.fr/plateforme-labellisee/         Key events

• Permanent staff members   Group picture                         Group picture archives

Dr Hélène CASTEL (DR2 Inserm)1        (33)235 14 66 30 - This email address is being protected from spambots. You need JavaScript enabled to view it.    - CV link
Dr M-Christine TONON (DR2 Inserm)2        (33)235 14 66 29 - This email address is being protected from spambots. You need JavaScript enabled to view it.   - CV link
Pr Pierrick GANDOLFO (PU)3        (33)235 14 66 11 - This email address is being protected from spambots. You need JavaScript enabled to view it.
      Assistant Director of the Doctoral School «  Integrative Biology, Health and Environment »                                       (Normandy University)  Web site
Dr Fabrice MORIN (MCU)4        (33)235 14 66 30 - This email address is being protected from spambots. You need JavaScript enabled to view it. - CV link
      Director of the master program « Neurosciences » -  Neuroscience program and contacts
Dr Vincent COMPÈRE (PU-PH)5        This email address is being protected from spambots. You need JavaScript enabled to view it.
Dr Emmanuel GERARDIN (PU-PH)6        This email address is being protected from spambots. You need JavaScript enabled to view it.
Dr Olivier LANGLOIS (PH)7                This email address is being protected from spambots. You need JavaScript enabled to view it.
Dr Laurence DESRUES (IRE CNRS)9        (33)235 14 66 11 - This email address is being protected from spambots. You need JavaScript enabled to view it.
Dr Martine DUBOIS (IE Inserm)10        (33)235 14 66 29 - This email address is being protected from spambots. You need JavaScript enabled to view it.


Cynthia CAMPART (ITA Rouen University, Novartis grant) 

• Graduate students

Daniele CAMPISI (Région Haute-Normandie Allocation)
Kleouforo Paul DEMBELE13 (Région Haute-Normandie Allocation) - Group picture
Alexandre MUTEL16 (Ministry Allocation) - Group picture
Benjamin PORET15 (Région Haute-Normandie Allocation) - Group picture

• Master students

Thomas CLAVIER - Group picture
François-Xavier FERRACCI (Internal Neurosurgeon)
Nicolas MAGNE (Internal Radiologist)
Mélanie ROUSSEL (Internal Urgentist)17 - Group picture


Institutional partners




Research team websitePublications   -   Grants and networks   -  News   -   Keys events

Our main objective is to investigate the role of vasoactive paracrine/autocrine signals as well as vascular circulating factors at the interface between astrocytes and the brain microvasculature, and the role of the vascular niche in the regulation of neurogenesis, gliomagenesis and/or neoangio-genesis. Our team reinforced by clinicians (Neurosurgery, Neuroradiology and Anesthesiology and Critical Care services, Rouen Hospital), currently develops a continuum from cognitive projects to translational and clinical research programs to build innovative therapeutics.







Full page GPCR   -   Brain tumors
Our recent main contributions lie in the demonstration of the expression of the vasoactive neuropeptide urotensin II (UII) and its G protein coupled receptor (GPCR) UT in different brain human glioma biopsies and their role, as chemotaxic regulators, in tumor cell adhesion and migration via original UT signaling switch and inhibitory control of autophagic processes.
In vivo, UT activation favors proangiogenic cell type recruitment, neoangiogenesis, necrosis and activation of invasive mechanisms contributing to glioma growth whereas UT receptor “antagonists” exhibit anti-tumoral properties, constituting original treatment strategies against glioblastoma.

                                                                     Full page Brain hemorrhage

In another physiopathological context, a new hypothesis suggests an alteration of the microvascular glio-endothelial unit leading to delayed ischemia after subarachnoid hemorrhage. We established that UII and the UT receptor are expressed in brain microvascular compartments, that UT receptor antagonists prevent the ischemic neurological deficits post-hemorrhage in mice and that UII levels in patient CSF and plasma are correlated with macrovasospasm post-hemorrhage and delayed. We are currently developing new promising approaches to treat this neurovascular disease in transgenic mice (KO-UT and Kin human UT) we have conceptualized and produced. Thus, developing promising compounds for targeted physiological or therapeutic actions becomes real challenge. We determined the signaling profile of UT, activated by UII or synthetic analogue peptides and showed that activities of the urotensinergic system are differently modulated by peptide biased ligands, pointing out the importance of ligand-specific receptor signaling signature in the cellular behaviour of GPCRs.                                                             

Clinical investigations:

• Vincent Compère - CCPPRB - Endozepines levels in plasma of septic patients - 2004-2007.
• Nathalie Godard - PHRC "EvalHospitam" - Endozepines levels in plasma of anorexic patients 2007– 2012.
• François Proust - PHRC “FASHE” - Elderly and subarachnoid hemorrage - 2008- 2012.
• François Proust, Hélène Castel and Vincent Compère Rouen CHU promoter Young researcher - UII levels in CSF and plasma of SAH patients - 2010 -2012.
• Vincent Compère - CCPPRB - Urotensin levels in plasma of septic patients - 2010-2012.







Institutional partners



Academic appeal and reputation

    Total of 102 publications (2012-2016) of the team including 43 original publications expect clinical reports, 3 international and national patents, 16 published abstracts of congress, 31 international conferences, seminars and oral communications, 6 PhD thesis and 8 MD hosted in the team (Master 2). Research projects of the team led to 5 original publications with IF>8. Collaborating creation of one national/international platform Cancer and Cognition (one web site); Board member of the ICCTF international group; board member of the 4th axis of CNO, the LRCC, the CSS1 Inserm commission (elected). Expertise recognition by Industry (consulting and contracts), charities and lay public.

     Coordination of the evaluation of doctoral school process in AERES and HCERES, co-direction of the EDnBISE doctoral normandie school, co-direction of the master BioMedical Sciences and the Speciality Neurosciences and Behavioral Sciences; co-direction of the diploma neurosciences and of a number of teaching units.


Patent 1Compère, V., Marguerite, C., Gandolfo, P., Arthaud, S., Desrues, L., Jarry, M. and Castel, H.  “Agonists of urotensin II receptor for the treatment of vascular dysfunctions during septic choc” PCT (N°EP2012/051166), 2012. International
Patent 2Castel, H., Dubois, M., Proust F., Gandolfo, P. et Compère, V.  «Ligands analogues de l’urotensine II pour la prévention des déficits neurologiques post-hémorragie sous-arachnoïdienne» (FR1356995, 16.07.2013).
Patent 3Castel, H., Desrues, L., Proust, F., Gandolfo, P. et Compère, V.  «Urotensine II : Biomarqueur diagnostic du vasospasme après hémorragie sous-arachnoïdienne» (FR1358502, 05.09.2013).


- 2017 -

  1. El Amki, M., Dubois, M., Lefevre-Scelles, A., Magne, N., Roussel, M., Clavier, T., Guichet, P.O., Gérardin, E., Compère, V. and Castel, H.: Long-lasting cerebral vasospasm, microthrombosis, apoptosis and paravascular alterations associated with neurological deficits in a mouse model of subarachnoid hemorrhage. Mol Neurobiol. doi: 10.1007/s12035-017-0514-6, (2017). (IF 6.19) NCBI
  2. Ghouili, I., Bahdoudi, S., Morin, F., Amri, F., Hamdi, Y., Coly, P.M., Walet-Balieu, M.L., Leprince, J., Vaudry, H., Vaudry, D., Zekri, S., Castel, H., Amri, M., Tonon, M.C. and Masmoudi-Kouki, O. : Endogenous expression of ODN-related peptides in  astrocytes contributes to cell protection against oxidative stress: Astrocyte-neuron crosstalk relevance for neuronal survival. Mol. Neurobiol. Doi: 10.1007/s12035-017-0630-3 (2017) (IF 6.19)
  3. Ursu, R., Carpentier, A., Metellus, P., Lubrano, V., Laigle-Donadey, F., Capelle, L., Guyotat, J., Langlois, O., Bauchet, L., Desseaux, K., Tibi, A., Chinot, O., Lambert, J., Carpentier, A.F. : Intracerebral injection of CpG oligonucleotide for patients with de novo glioblastoma-A phase II multicentric, randomised study. Eur. J. Cancer. 73:30-37 (2017) (IF 6.16).
  4. Besnier, E., Clavier, T., Tonon, M.C., Selim, J., Leceve-Scelles, A., Morin, F., Tamion F., Dureuil, B., Castel, H.  and Compère, V.:  Ketamine and etomidate downregulate the hypothalamic-pituitary-adrenal axis in an endotoxemic mouse model. Anesthesiology 127: 347-354 (2017) (IF 5.66)
  5. Castel, H., Denouel, A., Lange, M., Tonon, M.C., Dubois, M. and Joly, F. : Biomarkers associated with cognitive impairments in treated cancer patients: Potentiel predisposition and risk factor.  Front. Pharmacol.  doi: 10.3389/fphar.2017.00138 (2017). (IF 4.41) review NCBI
  6. Besnier, E., Clavier, T. and Compère, V. : The Hypothalamic-Pituitary-Adrenal Axis and Anesthetics: A Review. Anesth. Analg.  doi: 10.3389/fphar.2017.00138. (2017) (IF 3.83).
  7. Castel, H., Desrues, L., Joubert, J.E., Tonon, M.C., Prézeau, L., Chabbert, M., Morin, F. and Gandolfo, P. : The G protein-coupled receptor UT of the neuropeptide urotensin II displays structural and functional chemokine features. Front. Endocrinol. doi: 10.3389/fendo.2017.00076 (2017). (IF  3.675) Review NCBI
  8. Amri, F., Ghouili, J., Tonon, M.C., Amri, M. and Masmoudi-Kouki, O. : Hemoglobin-improved protection in cultured cerebral cortical astroglial cells: inhibition of oxidative stress and caspase activation. Front. Endocrinol. doi: 10.3389/fendo.2017.00067 (2017). (IF 3.675)
  9. Coly, P.M., Gandolfo, P., Castel, H. and Morin, F.: The autophagy machinery: a new player in chemotactic cell migration. Front. Neurosci. doi: 10.3389/fnins.2017.00078. (2017) (IF 3.398) review NCBI
  10. Guillebaud, F., Girardet, C., Abysique, A., Gaigé, S., Barbouche, R., Verneuil, J., Jean, A., Leprince, J., Tonon, M.C., Dallaporta, M., Lebrun, B. and Troadec, J.D. : Glial endozepines inhibit feeding-related autonomic functions by acting at the brainstem level. Front. Neurosci. 11:308. doi: 10.3389/fnins.2017.00308 (2017) (IF 3.398)
  11. Lange, M., Laviec, H., Castel, H., Heutte, N., Leconte, A., Léger, I., Giffard, B., Capel, A., Dubois, M., Clarisse, B., Coquan, E., Di Fiore, F., Gouérant, S., Bartélémy, P., Pierard, L., Fizazi, K. and Joly, F. : Impact of new generation hormone-therapy on cognitive function in elderly patients treated for a metastatic prostate cancer: Cog-Pro trial protocol. BMC Cancer.  doi: 10.1186/s12885-017-3534-8 (2017) (IF 3.29) NCBI
  12. Lefaucheur, R., Lebas,  A., Gérardin, E., Grangeon, L., Ozkul-Wermester, O., Aubier-Girard, C., Martinaud, O. and Maltête, D. : Leucoencephalopathy following abuse of sniffed heroin. J. Clin. Neurosci. 35:70-72 (2017) (IF 1.38) Specific clinical report
  13. Ferracci, F.X., Gilard, V., Cebula, H., Magne, N., Lejeune, J.P., Langlois, O. and Proust, F. : Growth of giant intracranial aneurysms: An aneurysmal wall disorder? Neurochirurgie 63:6-12 (2017) (IF 0.4) Specific clinical report

- 2016 -

  1. Lanfray, D., Caron, A., Roy, M.C., Laplante, M., Morin, F., Leprince, J., Tonon, M.C., and Richard, D. : Involvement of the Acyl-CoA binding domain containing 7 in the control of food intake and energy expenditure in mice. eLife pii: e11742. doi: 10.7554/eLife.11742. (2016) (IF 9.3)
  2. Coly, P.M., Perzo, N., Le Joncour, V., Lecointre, C., Schouft, M.T., Desrues, L., Tonon, M.C., Wurtz, O., Gandolfo, P., Castel, H. and Morin, F. : Chemotactic G protein-coupled receptors control cell migration by repressing autophagosome biogenesis. Autophagy 12:2344-2362 (2016) (IF 9.11) NCBI
  3. Lange, M., Heutte, N., Rigal, O., Noal, N., Kurtz, J.E., Lévy, C., Allouache, D., Rieux, C., Lefel, J., Clarisse, B., Veyret, C., Barthélémy, P., Longato, N., Castel, H., Eustache, F., Giffard, B. and Joly, F. : Decline in cognitive functions in elderly early-stage breast cancer patients after adjuvant treatment. The Oncologist  21:1337-1348 (2016) (IF 4.87) NCBI
  4. Louvel, G., Metellus, P., Noel, G., Peeters, S., Guyotat, J., Duntze, J., Le Reste, P.J., Dam Hieu, P., Faillot, T., Litre, F., Desse, N., Petit, A., Emery, E., Voirin, J., Peltier, J., Caire, F., Vignes, J.R., Barat, J.L., Langlois, O., Menei, P., Dumont, S.N., Zanello, M., Dezamis, E., Dhermain, F. and Pallud,  J. : Delaying standard combined chemoradiotherapy after surgical resection does not impact survival in newly diagnosed glioblastoma patients. Radiother. Oncol. 118:9-15 (2016). (IF 4.80)
  5. Martinaud, O., Mirlink, N., Bioux, S., Bliaux, E., Champmartin, C., Pouliquen, D., Cruypeninck, Y., Hannequin, D. and Gérardin, E. : Mirrored and rotated stimuli are not the same: A neuropsychological and lesion mapping study. Cortex. 78:100-114 (2016) (IF 4.71)
  6. Louvel. G., Metellus. P., Noël. G., Peeters, S., Guyotat, J., Duntze, J., Le Reste, P.J., DamHieu, P., Faillot, T., Litre, F., Desse, N., Petit, A., Emery, E., Voirin, J., Peltier, J., Caire, F., Vignes, J.R., Barat, J.L., Langlois, O., Menei, P., Dumont, S.N., Zanello, M., Dezamis, E.,Dhermain, F. and Pallud, J. : Delaying standard combined chemoradiotherapy after surgical resection does not impact survival in newly diagnosed glioblastoma patients. Radiother. Oncol. 118:9-15 (2016).  (IF 4.36)
  7. Douiri,  S., Bahdoudi,  S., Hamdi, Y., Cubì, R., Basille, M., Fournier, A., Vaudry, H., Tonon, M.C., Amri, M., Vaudry, D. and Masmoudi-Kouki, O. : Involvement of endogenous antioxidant systems in the protective activity of pituitary adenylate cyclase-activating polypeptide against hydrogen peroxide-induced oxidative damages in cultured rat astrocytes. J. Neurochem. 137:913-930 (2016). (IF 4.28)
  8. Grangeon, L., Paquet, C., Bombois, S., Quillard-Muraine, M., Martinaud, O., Bourre, B., Lefaucheur, R., Nicolas, G., Dumurgier, J., Gerardin, E., Jan, M., Laplanche, J.L., Peoc'h, K., Hugon, J., Pasquier, F., Maltête, D., Hannequin, D. and Wallon D. : Differential diagnosis of dementia with high levels of cerebrospinal fluid Tau protein. J. Alzheimer's Dis. 51:905-913 (2016) (IF 4.15)
  9. Gilard, V., Alexandru, C., Proust, F., Derrey, S., Hannequin, P. and Langlois, O. : Pituitary metastasis: is there still a place for neurosurgical treatment? J Neurooncol. 126:219-224 (2016). (IF 3.07) review
  10. Hallouard, F., Mehenni, L., Lahiani-Skiba, M., Anouar, Y., Skiba, M. : Solid dispersions for oral administration: An overview of the methods for their preparation. Curr Pharm Des. 22:4942-4958 (2016). (IF = 3.05)
  11. Clavier, T., Besnier, E., Lefevre-Scelles, A., Lanfray, D., Masmoudi, O., Pelletier, G., Castel, H., Tonon, M.C. and Compère, C. : Increased hypothalamic levels of endozepines, endogenous ligands of benzodiazepine receptors, in a rat model of sepsis. Shock  45:653-659 (2016) (IF 3.04)
  12. Joly, F., Heutte, N., Duclos, B., Noal, S., Léger-Hardy, I., Dauchy, S., Longato, N., Desrues, L., Houede, N., Lange, M., Sevin, E., Rieux, C., Clarisse, B., Castel, H. and Escudier, B. : Prospective evaluation of the impact of antiangiogenic treatment on cognitive functions in metastatic renal cancer. Eur. Urol. Focus 2:642-649 (2016). NCBI
  13. Compère, V., Daccache, G., Amdjar, N., Fourdrinier, V., Jmoriceau, J., Foutel, A., Frebourg, N., Mourgeon, E., Houivet, E., Dureuil, B. : Bacterial colonization is decreased after tunneling femoral perineural catheters. Minerva Anestesiol. 82:1288-1295 (2016). (IF = 2.03) Specific clinicat report
  14. Gilard, V., Proust, F., Gerardin, E., Lebas, A., Chastan, N., Fréger, P., Parain, D. and Derrey, S. : Usefulness of multidetector-row computerized tomographic angiography for the surgical planning in stereoelectroencephalography. Diagn. Interv. Imaging 97:333-337 (2016). (IF 1.44) Specific clinical report
  15. Cruypeninck, Y., Dubourg, B., Michelin, P., Godin, B., Savoye-Collet, C., Gérardin, E. and Dacher, J.N. : Pacemakers and MRI: A protocol in line with international guidelines and approved by the SFICV (French Society of Cardiovascular Imaging). Diagn. Interv. Imaging (2016) doi:10.1016/j.diii.2016.06.024. (IF 1.44) Specific clinical report
  16. Compère, V., Abily, J., Moriceau, J., Gouin, A., Veber, B., Dupont, H., Lorne, E., Fellahi, J.L., Hanouz, J.L., Gerard, J.L., Sibert, L. and Dureuil, B. : Residents in tutored practice exchange groups have better medical reasoning as measured by script concordance test: a controlled, nonrandomized study. J. Clin. Anesth. 32:236-241 (2016). (IF 1.28) Specific clinical report
  17. Melot, A., Labarre, A., Vanhulle, C., Rondeau, S., Brasseur, M., Gilard, V., Castel, H., Marret, S. and Proust, F. : Neurodevelopmental long-term outcome in children with hydrocephalus requiring neonatal surgical treatment. Neurochirurgie 62:94-99 (2016) (IF 0.4) Specific clinical report
  18. Pruvot, A.S., Curey, S., Derrey, S., Castel, H. and Proust, F. : Giant intracranial aneurysms in the paediatric population: Suggested management and a review of the literature. Neurochirugie 62:20-24  (2016) (IF 0.4) Specific clinical report
  19. Gilard, V., Ferracci, F.X., Langlois, O., Derrey, S., Proust, F. and Curey, S. : Effects of melatonin in the treatment of asthenia in aneurysmal subarachnoid hemorrhage. Neurochirurgie 62:295-299 (2016) (IF 0.4) Specific clinical report
  20. Cugy, E., Leroi , A.M., Kerouac-Laplante, J., Dehail, P., Joseph, P.A., Gerardin, E., Marie, J.P. and Verin, É.: Effect of submental sensitive transcutaneous electrical stimulation on virtual lesions of the oropharyngeal cortex. Ann. Phys. Rehabil. Med. 59:94-99 (2016) Specific clinical report

- 2015 -

  1. Lecointre, C., Desrues, L., Joubert, J.E., Perzo, N., Guichet, P.O., Le Joncour, V., Brulé, C., Chabbert, M., Leduc, R., Prézeau, L., Laquerrière, A., Proust, F., Gandoldo, P., Morin, F. and Castel, H. : Signaling switch of the urotensin II vasoactive peptide GPCR : Prototypic chemotaxic mechanism in glioma. Oncogene 34:5080-5094 (2015). (IF 8.6) NCBI
  2. Pallud, J., Audureau, E., Noel, G., Corns, R., Lechapt-Zalcman, E., Duntze, J., Pavlov, V., Guyotat, J., Hieu, P.D., Le Reste, P.J., Faillot, T., Litre, C.F., Desse, N., Petit, A., Emery, E., Voirin, J., Peltier, J., Caire, F., Vignes, J.R., Barat, J.L., Langlois, O., Dezamis, E., Parraga, E., Zanello, M., Nader, E., Lefranc, M., Bauchet, L., Devaux, B., Menei, P. and Metellus, P.: Long-term results of carmustine wafer implantation for newly diagnosed glioblastomas: a controlled propensity-matched analysis of a French multicenter cohort. Neuro Oncol. 17:1609-1619 (2015). (IF 6.77) NCBI
  3. Bouchal, F., Skiba, M., Chaffai, N., Hallouard, F., Fatmi, S. and Lahiani-Skiba, M.: Fast dissolving cyclodextrin complex of piroxicam in solid dispersion part I: influence of β-CD and HPβ-CD on the dissolution rate of piroxicam. Int. J. Pharm. 478:625-632 (2015). (IF 3.65)
  4. Gach, K., Belkacemi, O., Lefranc, B., Perlikowski, P., Masson, J., Do-Rego, J.C., Galas, L.,  Schapman, D., Lamthari, R., Tonon, M.C., Vaudry, D., Chuquet, J. and Leprince, J. : Detection, characterization and biological activities of [bisphospho-Thr3,9]ODN, an endogenous molecular form of ODN released by astrocytes. Neuroscience. 290:472-484 (2015). (IF 3.33)
  5. Skiba-Lahiani, M., Hallouard, F., Mehenni, L., Fessi, H. and Skiba, M.: Development and characterization of oral liposomes of vegetal ceramide based amphotericin B having enhanced dry solubility and solubility. Mater. Sci. Eng. 48:145-149 (2015). (IF 3.08)
  6. Joly, F., Giffard, B., Rigal, O., Lange, M., LeFel, J., Schagen, S., Ahles, T., Vardy, J., Pancré, V., Dubois, M. and Castel, H. : Impact of cancer and treatments on cognitive functions: Update of the advances in research from the Paris International Cognition and Cancer Task Force Symposium. J. Pain Sympto. Manage 50:830-841 (2015) (IF 2.8). Review NCBI
  7. Hamdi, Y., Kaddour, H., Vaudry, D., Leprince, J., Zarrouk, A., Hammami, M., Vaudry, H.,Tonon, M.C., Amri, M. and Masmoudi-Kouki, O. : Octadecaneuropeptide ODN prevents hydrogen peroxide-induced oxidative damage of biomolecules in cultured rat astrocytes. Peptides 71:56-65 (2015). (IF 2.61)
  8. El Amki, M., Clavier, T., Perzo, N., Bernard, R., Guichet, P.O. and Castel, H.: Hypothalamic, thalamic and hippocampal lesions in the mouse MCAO model: potential involvement of deep cerebral arteries? J. Neurosci. Methods 254:80-85 (2015). (IF 2.0) Review NCBI
  9. Compère, V., Moriceau, J., Gouin, A., Guitard, P.G., Damm, C., Provost, D., Gillet, R., Fourdrinier, V. and Dureuil, B. : Residents in tutored practice exchange groups have better medical reasoning as measured by the script concordance test: A pilot study. Anaesth. Crit. Care Pain Med. 34:17-21 (2015). Specific clinical report
  10. Derrey, S., Chastan, N., Maltete, D., Verin, E., Dechelotte, P., Lefaucheur, R., Proust, F., Freger, P., Leroi, A.M., Weber, J. and Gourcerol, G. : Impact of deep brain stimulation on pharyngo-esophageal motility: a randomized cross-over study. Neurogastroenterol. Motil. 27:1214-1222 (2015). (IF 3.6) Specific clinical report
  11. Martinaud, O., Pouliquen, D., Parain, D., Goldenberg, A., Gérardin, E., Hannequin, D., Altarelli, I., Ramus, F., Hertz-Pannier, L., Dehaene-Lambertz, G. and Cohen, L. : Impaired functional differentiation for categories of objects in the ventral visual stream: A case of developmental visual impairment. Neuropsychologia 77:52-61 (2015). (IF 3.3) Specific clinical report
  12. Besnier, E., Damm, C., Jardel, B., Veber, B., Compère, V. and Dureuil, B. : Dispatcher-assisted cardiopulmonary resuscitation protocol improves diagnosis and resuscitation recommendations for out-of-hospital cardiac arrest. Emerg. Med. Australas. doi: 10.1111/1742-6723.12493 (2015). (IF 1.30) Specific clinical report
  13. Proust, F.: Treatment of esthesioneuroblastoma: a double approach? Neurochirurgie 61:54 (2015). Quesnel, A ., Veber, B., Proust, F., Agasse, E., Beuret Blanquart, F. and Verin, E. : What are the perspectives for ventilated tetraplegics? A French retrospective study of 108 patients with cervical spinal cord injury. Ann. Phys. Rehabil. Med. 58:74-77 (2015). (IF 0.4) Specific clinical report
  14. Thines, L., Proust, F., Marinho, P., Durand, A., van der Zwan, A., Regli, L. and Lejeune, J.P. : Giant and complex aneurysms treatment with preservation of flow via bypass technique. Neurochirurgie 2015 Jun 10. pii: S0028-3770(15)00079-X. doi:10.1016/j.neuchi.2015.03.008. (IF 0.4) Review

 - 2014 -

  1. Jarry, M , Lecointre, C., Malleval, C., Desrues, L., Schouft, M.T., Le Joncour, V., Liger, F., Lyvinec, G.,  Joseph, B., Loaëc, N., Meijer, L., Honnorat, J., Gandolfo, P. and Castel H. :  Impact of meriolins, a new class of cyclin-dependent kinase inhibitors,on malignant glioma proliferation and neo-angiogenesis. Neuro Oncol. 16:1484-1498 (2014). (IF 6.2) NCBI
  2. Brulé, C.*, Perzo, N.*, Joubert, J.E.*, Sainsily, X., Leduc, R.**, Castel, H.** and Prézeau, L.** : Biased signaling regulates the pleiotropic effects of the urotensin II receptor to modulate its cellular behaviors. FASEB J. 28:5148-5162 (2014). (IF 5.7) NCBI
    *co-first authors; **, co-last authors
  3. Clavier, T., Tonon, M.C., Foutel, A., Besnier, E., Lefevre-Scelles, A., Morin, F., Gandolfo, P., Tuech, J.J., Quillard, M., Veber, B., Dureuil, B., Castel, H. and Compère, V.: Increased plasma levels of endozepines, endogenous ligands of benzodiazepine receptors, during systemic inflammation and sepsis: a prospective observational study. Crit. Care, 18(6):633 doi: 10.1186/s13054-014-0633-7  (2014). (IF = 5.1) NCBI
  4. Dubois, M., Lapinte, N., Villier V, Lecointre, C., Roy, V., Tonon, M.C., Gandolfo, P., Joly, F., Hilber, P. and Castel, H.: Chemotherapy-induced long-term alteration of executive functions and hippocampal cell proliferation: Role of glucose as adjuvant. Neuropharmacology 79:234-248 (2014). (IF 4.8) NCBI
  5. Jouanno, L.A., Chevalier, A., Sekkat, N., Perzo, N., Castel, H., Romieu, A., Lange, N., Sabot, C. and Renard, P.Y.: Kondrat'eva ligation: Diels-Alder-based irreversible reaction for bioconjugation. J. Org. Chem.  79:10353-10366 (2014). (IF 4.6)
  6. Dubois, M., Le Joncour, V., Tonon, M.C., Anouar, Y., Gandolfo, P., Proust, F., Morin, F., Joly, F., Hilber, P. and Castel, H. : Evaluation of the impact of everolimus on cognitive function, cerebral metabolism, and hippocampal cell proliferation.  PloS One 9(12):e113533 doi: 10.1371/journal.pone.0113533 (2014). (IF 3.8)
  7. Pelé, J., Moreau, M., Abdi, H., Rodien, P., Castel, H. and Chabbert, M. : Comparative analysis of sequence covariation methods to mine evolutionary hubs: Examples from selected GPCR families. Proteins 82:2141-2156 (2014). (IF 2.9)
  8. Martinaud, O., Mirlin,k N., Bioux, S., Bliaux, E., Lebas, A., Gerardin, E., Hannequin, D. : Agnosia for mirror stimuli: a new case report with a small parietal lesion. Arch. Clin. Neuropsychol. 29:724-728 (2014) (IF 1.9) Specific clinical report
  9. Lévêque, S., Derrey, S., Castel, H. and Proust, F. : The mini supra-orbital approach for cerebral aneurysm of the anterior portion of the circle of Willis. Acta Neurochir. 119:21-24 (2014). (IF 1.8) Specific clinical report
  10. Meling, T.R., Proust, F., Gruber, A., Niemela, M., Regli, L., Roche, P.H. and Vajkoczy, P. : On apples, oranges, and ARUBA. Acta Neurochir. (Wien) 156:1775-1779 (2014). (IF 1.8) Specific clinical report
  11. Ozkul-Wermester, O., Guegan-Massardier, E., Triquenot, A., Borden, A., Perot, G. and Gérardin, E. :Increased blood-brain barrier permeability on perfusion computed tomography predicts hemorrhagic transformation in acute ischemic stroke. Eur. Neurol. 72:45-53 (2014). (IF 1.5) Specific clinical report
  12. Vandendriessche, A., Proust, F., Frébourg, N., Etienne, M., Caron, F. : H-02: Abcès cérébraux : rôle sous-estimé de Staphylococcus ? Med. Mal. Infect. 44 :48 (2014). (IF 0.9) Specific clinical report
  13. Besnier, E., Clavier, T., Castel, H., Gandolfo, P., Morin, F., Tonon, M.C., Marguerite, C., Veber, B., Dureuil, B. and Compère, V. : Interaction between hypnotic agents and the hypothalamic-pituitary-adrenocorticotropic axis during surgery. Ann. Fr. Anesth Reanim. 33:256-265 (2014). (IF 0.8) Review
  14. Compère, V. :Which is the legal risk associated with the day surgery for anaesthesiologist? Ann. Fr. Anesth. Reanim. 33:153-154 (2014). (IF 0.8) Specific clinical report
  15. Royon, V., Rabehenoina, C., Tourrel, F., Compère, V. and Dureuil, B. : Remote cerebellar hemorrhage as an early and potentially lethal complication of a discal lumbar herniation surgery. Ann. Fr. Anesth. Reanim. doi: 10.1016/j.annfar.2013.12.009 (2014). (IF 0.8) Specific clinical report
  16. Bennani, O., Derrey, S., Langlois, O., Castel, H., Laquerrière, A., Fréger, P. and Proust, F. : Brain metastasis from renal cell carcinoma. Neurochirurgie 60:12-16 (2014). (IF 0.4) Specific clinical report
  17. Derrey, S., Penchet, G., Thines, L., Lonjon, M., David, P., Bataille, B., Emery, E., Lubrano, V., Laguarrigue, J., Bresson, D., Pelissou, I., Irthum, B., Lejeune, J.P., Proust, F. : French collaborative group series on giant intracranial aneurysms: Current management. Neurochirurgie. Doi: 10.1016/j.neuchi.2013.11.006 (2014). (IF 0.4) Specific clinical report
  18. Gilard, V., Curey, S., Derrey, S., Perez A., Proust, F. : Cervical spine fractures in patients with ankylosing spondylitis: Importance of early management. Neurochirurgie. Doi:10.1016/j.neuchi.2014.06.008 (2014). (IF 0.4) Specific clinical report
  19. Proust, F., Roche, P.H., Meling, T.R. : Does ARUBA study improve our knowledge as regards the management of unruptured brain arteriovenous malformations? Neurochirurgie 60:2-4 (2014). (IF 0.4) Specific clinical report
  20. Thines, L., Durand, A., Penchet, G., Proust, F., Lenci, H., Debailleul, A., Lejeune, J.P. and Pelissou-Guyotat, I. : Microsurgical neurovascular anastomosis: The example of superficial temporal artery to middle cerebral artery bypass. Technical principles. Neurochirurgie 60:158-164 (2014). (IF 0.4) Specific clinical report
  21. Tollard, E., Perot, G., Clavier, E., Gerardin, E. : Imaging of giant cerebral aneurysms. Neurochirurgie doi:10.1016/j.neuchi.2013.10.124 (2014). (IF 0.4) Specific clinical report
  22. Marguet, F., Proust, F., Crahes, M., Basset, C., Joly-Helas, G., Chambon, P. et Laquerrière, A. : Malignant meningioma with adenocarcinoma-like metaplasia: A rare entity to be not misdiagnosed]. Ann. Pathol. 34:223-227 (2014). Epub 2014 May 17. (IF 0.3) Specific clinical report

- 2013 -

  1. Lanfray, D., Arthaud, S., Ouellet, J., Compère, V., Do Rego, J.L., Leprince, J., Lefranc, B., Castel, H., Bouchard, C., Monge-Roffarello, B., Richard, D., Pelletier, G., Vaudry, H., Tonon, M.C. and Morin, F. : Gliotransmission and brain blucose sensing: Critical role of endozepines. Diabetes 62:801-810 (2013). (IF 8.5) NCBI
  2. Chevalier, A., Dubois, M., Le Joncour, V., Dautrey, S., Lecointre, C., Romieu, A., Renard, P.Y., Castel, H. and Sabot, C.: Synthesis, biological evaluation, and in vivo imaging of the first camptothecin-fluorescein conjugate.  Bioconjug. Chem. 24:1119-1133 (2013). (IF 5.2) NCBI
  3. Lefaucheur, R., Derrey, S., Borden, A., Wallon, D., Ozkul, O., Gérardin, E., Maltête, D. : Post-operative edema surrounding the electrode: an unusual complication of deep brain stimulation. Brain Stimul. 6:459-460 (2013). (IF 5.4) Specific clinical report
  4. Aury-Landas, J., Bougeard G., Castel H., Hernandez-Vargas, H., Drouet, A., Latouche, J-B, Férec, C., Schouft, M.T., Tournier, I., Leroux, D., Lasset, C., Coupier, I., Caron, O., Herceg, Z., Frebourg, T. and Flaman, J.M.: Germline copy number variation of genes involved in chromatin remodeling in families suggestive of Li-Fraumeni syndrome with brain tumours. Eur. J. Hum. Genet. 21:1369–1376 (2013). (IF 4.3)
  5. Giabicani, M., Compère, V., Fourdrinier, V. and Dureuil, B.: Is sickle cell disease a possible risk factor for peripheral neuropathy after popliteal sciatic nerve block? Br. J. Anaesth. 111:508-510 (2013). (IF 4.2)
  6. Kaddour, H., Hamdi, Y., Vaudry, D., Basille, M., Desrues, L., Leprince, J., Castel, H., Vaudry, H., Tonon, M.C., Amri, M. and Masmoudi-Kouki, O.: The octadecaneuropeptide ODN prevents 6-hydroxydopamine-induced apoptosis of cerebellar granule neurons through a PKC-MAPK-dependent pathway. J. Neurochem. 125:620-633 (2013). (IF 4.0)
  7. Azuma, M., Wada, K., Leprince, J., Tonon, M.C., Uchiyama, M., Takahashi, A., Vaudry, H. and Matsuda K.: The octadecaneuropeptide stimulates somatolactin release from cultured goldfish pituitary cells. J. Neuroendocrinol. 25:312-321 (2013). (IF 3.3)
  8. Donnet, A., Valade, D., Houdart, E., Lanteri-Minet, M., Raffaelli, C., Demarquay, G., Hermier, M., Guegan-Massardier, E., Gerardin, E., Geraud, G., Cognard, C., Levrier, O., Lehmann, P. : Primary cough headache, primary exertional headache, and primary headache associated with sexual activity: a clinical and radiological study. Neuroradiology 55:297-305 (2013). (IF 2.7)
  9. Joyard, Y., Le Joncour, V., Castel, H., Diouf, C.B., Bischoff, L., Papamicaël, C., Levacher, V., Vera, P. and Bohn, P.: Synthesis and biological evaluation of a novel (99m)Tc labeled 2-nitroimidazole derivative as a potential agent for imaging tumor hypoxia.  Bioorg. Med. Chem. Lett. 23:3704-3708 (2013). (IF 2.3)
  10. Tonon, M.C., Lanfray, D., Castel, H., Vaudry, H. and Morin, F. : Hypothalamic glucose-sensing: role of Glia-to-neuron signaling. Horm. Metab. Res. 45:955-959 (2013). (IF 2,0) Review
  11. Ozkul, O., Borden, A., Guégan-Massardier, E., Proust, F., Wallon, D., Perot, G., Maltête, D. and Lefaucheur, R.: A case of spontaneous intracranial hypotension presenting as isolated permanent neck pain. Clin. Neurol. Neurosurg. 115:2551-2553 (2013). (IF 1.2) Specific clinical report
  12. Caremel, R., Hamel, O., Gérardin, E., Lenormand, L., Parker, F., Lefort, M., Grise, P. and Perrouin-Verbe , B.: Post-traumatic syringomyelia: What should know the urologist? Prog. Urol. 23:8-14 (2013). (IF 0.8) Specific clinical report
  13. Calvacante, T., Derrey, S., Curey, S., Langlois, O., Fréger, P., Gérardin, E., Castel, H. and Proust, F.: Distal middle cerebral artery aneurysm: A proposition of microsurgical management. Neurochirurgie 59:121-127 (2013). (IF 0.4) Specific clinical report
  14. Foulongne, E., Derrey, S., Ould Slimane, M., Lévêque, S., Tobenas, A.C., Dujardin, F., Fréger, P., Chassagne, P. and Proust, F.: Lumbar spinal stenosis: which predictive factors of favorable functional results after decompressive laminectomy? Neurochirurgie 59:23-29 (2013). (IF 0.4) Specific clinical report
  15. Gilard, V., Curey, S., Tollard, E. and Proust, F.: Coincidental vascular anomalies at the foramen magnum: Dural arteriovenous fistula and high flow aneurysm on perimedullary fistula. Neurochirurgie 59:210-213 (2013). (IF 0.4) Specific clinical report
  16. Melot, A., Curey-Lévêque, S., Derrey, S., Gérardin, E., Borden, A., Fréger, P. and Proust, F.: Endoscopic 3rd ventriculocisternostomy: Procedural complications and long-term dysfunctions? Neurochirurgie 59:165-170 (2013). (IF 0.4) Specific clinical report
  17. Pruvot, A.S., Curey, S., Derrey, S., Castel, H. and Proust, F.: Giant intracranial aneurysms in paediatric population : Suggested management and a review of the litterature. Neurochirurgie doi : 10.1016/j.neuchi.2013.06.004 (2013). (IF 0.4) Review
  18. Scherrer, V., Compère, V., Loisel, C. and Dureuil, B.: Cardiac arrest from local anesthetic toxicity after a field block and transversus abdominis plane block: a consequence of miscommunication between the anesthesiologist and surgeon. A Case Rep. 2013 Dec 1;1(5):75-6. doi: 10.1097/ACC.0b013e3182973a3f. Specific clinical report
  19.  Tonon, M.C., Leprince, J., Morin, F., Gandolfo, P., Compère, V., Pelletier, G., Malagon, M., and Vaudry, H: Endozepines. In "Handbook of Biological Active Peptides", A.J. Kastin Edt, Elsevier, pp 760-765 (2013). Second edition. Review

- 2012 -

  1. Do-Régo, J.-L., Seong, J.Y., Burel, D., Leprince, J., Vaudry, D., Luu-The, V., Tonon, M.C., Tsutsui, K., Pelletier, G. and Vaudry, H.: Regulation of neurosteroid biosynthesis by neurotransmitters and neuropeptides. Front. Neuroendocrinol. doi: 10.3389/fendo.2012.00004 (2012). (IF 7.9) Review
  2. Cruz-Garcia, D., Diaz-Ruiz, A., Rabanal-Ruiz, Y., Peinado, J.R., Gracia-Navarro, F., Castano, J.P., Montero-Hadjadje, M., Tonon, M.C., Vaudry, H., Anouar, Y., Vazquez-Martinez, R. and Malagon, M.M.: The Golgi-associated long coiled-coil protein NECCI participates in the control of the regulated secretory pathway in PC12 cells. Biochem. J. 443:387-396 (2012). (IF 4.7)
  3. Chabbert M., Castel H., Pelé J., Legendre R., Devillé J. and Rodien P. Evolution of class A G-protein-coupled receptors: Implications for molecular modeling. Current Med. Chem. 19:1110-1118 (2012). (IF 4.1) Review
  4. Desrues, L., Lefebvre, T., Lecointre, C., Schouft, M.T., Leprince, J., Compère, V., Morin, F., Proust, F., Gandolfo, P., Tonon, M.C., and Castel, H.: Down-regulation of GABAA receptor via promiscuity with the vasoactive peptide urotensin II receptor. Potential involvement in astrocyte plasticity. PLoS One 7:e36319. doi:10.1371/journal.pone.0036319 (2012). (IF 3.7)
  5. Hamdi, Y., Kaddour, H., Vaudry, D., Bahdoudi, S., Douiri, S., Leprince, J., Castel, H., Vaudry, H., Tonon, M.C., Amri, M. and Masmoudi-Kouki, O.: The octadecaneuropeptide ODN protects astrocytes against hydrogen peroxide-induced apoptosis via a PKA/MAPK-dependent mechanism. PloS One 7, e42498 (2012). (IF 3.7)
  6. Martinaud, O., Pouliquen, D., Gérardin, E., Loubeyre, M., Hirsbein, D., Hannequin, D. and Cohen, L.: Visual agnosia and posterior cerebral artery infarcts: an anatomical-clinical study. PLoS One 7:e30433. doi:10.1371/journal.pone.0030433 (2012). (IF 3.7)
  7. Curey, S., Derrey, S., Hannequin, P., Hannequin, D., Fréger, P., Muraine, M., Castel, H. and Proust, F.: Validation of the superior interhemispheric approach for tuberculum sellae meningioma. J. Neurosurg. 117:1013-1021 (2012). (IF 3.1)
  8. Marie, I., Tollard, E., Gerardin, E. and Guegan-Massardier, E.: Spontaneous intracranial hypotension syndrome in systemic sclerosis. QJM 105:177-179 (2012). (IF 2.4)
  9. Marini, H., Merle, V., Derrey, S,. Lebaron, C., Josset, V., Langlois, O., Gilles Baray,  M., Frébourg, N., Proust, F. and Czernichow, P.: Surveillance of unplanned return to the operating theatre in neurosurgery combined with a mortality—morbidity conference: results of a pilot survey. BMJ Qual. Saf. 21:432-438 (2012). (IF 2.4)
  10. Hamdi, Y., Kaddour, H., Vaudry, D., Douiri, S.L., Bahdoudi, S., Leprince, J., Castel, H., Vaudry, H., Amri, M., Tonon, M.C. and Masmoudi-Kouki, O.: The stimulatory effect of the octadecaneuropeptide ODN on astroglial antioxidant enzyme systems is mediated through a GPCR. Front. Endocrinol. doi: 10.3389/fendo.2012.00138 (2012).
  11. Derrey, S., Charpentier, C., Gérardin, E., Langlois, O., Touchais, J.Y., Lerebours, E., Proust, F. and Laquerrière, A.: Inflammatory pseudotumor of the cerebellum in a patient with Crohn's disease. World Neurosurg. 77:201.e13-6. doi:10.1016/j.wneu.2011.05.034 (2012). (IF 1.8) Specific clinical report
  12. Roux, N., Lévêque, S., Freguin-Bouilland, C., Dautreaux, B., Proust, F., Thuillez, C. and Plissonnier, D.: A kinetic study of SDF-1, VEGF and MCP-1 blood and tissue levels after aortic transplantation in mice. Acta Histochem. 114:636-638 (2012). (IF 1.6) Specific clinical report
  13. Derrey, S., Lebas, A., Parain, D., Baray, M.G., Marguet, C., Fréger, P. and Proust, F.: Delayed intracranial hematoma following stereoelectroencephalography for intractable epilepsy:case report. J. Neurosurg. Pediatr. 10:525-528 (2012). (IF 1.6) Specific clinical report
  14. Godefroy, A., Derrey, S., Laquerrière, A., Perot, G., Proust, F. and Gérardin, E.: Perfusion MR imaging and MR spectroscopy of gemistocytic astrocytoma. J. Neuroradiol. 39:190-194 (2012). (IF 1.2) Specific clinical report
  15. Bourret, B., Compère, V., Torre, S., Azhougagh, Provost D., Rachet B., Gillet R., Rieu M., Marpeau L. and Dureuil B.: Evaluation de l'utilisation du sulfate de magnésium dans la prévention secondaire de l'éclampsie. Ann. Fr. Anesth. Reanim. 31:933-936 (2012). (IF 0.8) Specific clinical report
  16. Hannequin, P., Melot, A., Triquenot, A., Fréger, P. and Proust, F. :Rebleeding from a vertebral artery dissection in a child: an inflammatory vasculopathy? Neurochirurgie 58:30-33 (2012).   (IF 0.3) Specific clinical report 
  17. Hardy, H., Tollard, E., Derrey, S., Delcampe, P., Péron, J.M., Fréger, P. and Proust, F.: Clinical and ossification outcome of custom-made hydroxyapatite prothese for large skull defect. Neurochirurgie 58:25-29 (2012). (IF 0.3) Specific clinical report
  18. Lefaucheur, R., Derrey, S., Martinaud, O., Wallon, D., Chastan, N., Gérardin, E., Hannequin, D. and Maltête, D.: Early verbal fluency decline after STN implantation: is it a cognitive microlesion effect? J. Neurol. Sci. 321:96-99 (2012). (IF 0.1) Specific clinical report
  19. Proust, F., Derey, S., Lavabre, O. and Castel, H.: Hypertension intracrânienne. BMC Neurology 17:1-14 (2012). Review

- 2011 -

  1. Lefaucheur, R., Bouwyn, J.P., Ahtoy, P., Gérardin, E., Derrey, S. and Maltête, D.: Teaching neuroimages: punctuate and curvilinear enhancement peppering the pons responsive to steroids. Neurology 77:e57-8. doi:10.1212/WNL.0b013e31822cfa4a (2011). (IF 8.3)
  2. Beaussier, H., Naggara, O., Calvet, D., Joannides, R., Guegan-Massardier, E., Gerardin, E., Iacob, M., Laloux, B., Bozec, E., Bellien, J., Touze, E., Masson, I., Thuillez, C., Oppenheim, C., Boutouyrie, P. and Laurent S.: Mechanical and structural characteristics of carotid plaques by combined analysis with echotracking system and MR imaging. JACC Cardiovasc. Imaging. 4:468-477 (2011). (IF 5.4)
  3. Le Marec, O., Neveu, C., Lefranc, B., Dubessy, C., Boutin, J.A., Do Rego, J.C., Costentin, J., Tonon, M.C., Tena-Sempere, M., Vaudry, H. and Leprince, J.: Structure-activity relationships of a series of analogs of the RFamide peptide 26RFa. J. Med. Chem. 54:4806-4814 (2011). (IF 5.3)
  4. Baïet B., Burel C., Saint-Jean B., Louvet R., Menu-Bouaouiche L., Kiefer-Meyer M.C., Mathieu-Rivet E., Lefebvre T., Castel H., Carlier A., Cadoret J.P., Lerouge P., Bardor M.: N-glycans of Phaeodactylum tricornutum diatom and functional characterization of its N-acetylglucosaminyltransferase I enzyme. J. Biol. Chem. 286:6152-64 (2011). (IF 5.3)
  5. Hamdi, Y., Masmoudi-Kouki, O., Kaddour, H., Belhadj, F., Gandolfo, P., Vaudry, D., Mokni, M., Leprince, J., Hachem, R., Vaudry, H., Tonon, M.C. and Amri, M.: Protective effects of the octadecaneuropeptide on hydrogen peroxide-induced oxidative stress and cell death in cultured rat astrocytes. J. Neurochem. 118:416-428 (2011). (IF 4.1)
  6. Masmoudi-Kouki, O., Douiri, S., Hamdi, Y., Kaddour, H., Bahdoudi, S., Vaudry, D., Basille, M., Leprince, J., Fournier, A., Vaudry, H., Tonon, M.C. and Amri, M. : Pituitary adenylate cyclase-activating polypeptide protects astroglial cells against oxidative stress-induced apoptosis. J. Neurochem. 117:403-411 (2011). (IF 4.1)
  7. Derrey, S., Lefaucheur, R., Proust, F., Chastan, N., Leveque, S., Gerardin, E., Freger, P. and Maltete D. : The unsuccessful placement of a deep brain stimulation electrode due to a brain shift induced by air invasion: case report. Parkinsonism Relat. Disord. 17:393-394 (2011). (IF 3.8)
  8. Botia, B., Jolivel, V., Burel, D., Le Joncour, V., Roy, V., Naassila, M., Bénard, M., Fournier, A., Vaudry, H. and Vaudry, D.: Neuroprotective effects of PACAP against ethanol-induced toxicity in the developing rat cerebellum. Neurotox. Res. 19:423-434 (2011). (IF 3.5)
  9. Derrey, S., Ouelaa, W., Lecointre, M., Maltete, D., Chastan, N., Leroi, A.M., Proust, F., Freger, P., Weber, J. and Gourcerol, G.: Effect of unilateral subthalamic deep brain stimulation on rat digestive motor activity. Neuroscience 195: 89-99 (2011). (IF 3.4)
  10. Matsuda, K., Wada, K., Azuma, M., Leprince, J., Tonon, M.C., Sakashita, A., Maruyama, K., Uchiyama, M. and Vaudry, H. : The octadecaneuropeptide exerts an anxiogenic-like action in goldfish. Neuroscience 181:100-108 (2011). (IF 3.4)
  11. Jenks, B.J., Galas, L., Kuribara, M., Desrues, L., Kidane, A.H., Vaudry, H., Scheenen, W.J., Roubos, E.W. and Tonon, M.C.: Analysis of the melanotrope cell neuroendocrine interface in two amphibian species, Rana ridibunda and Xenopus laevis: a celebration of 35 years of collaborative research. Gen. Comp. Endocrinol. 170:57-67 (2011). (IF 3.3) review
  12. Lévêque, S., Derrey, S., Martinaud, O., Gérardin, E., Hannequin, P., Langlois, O., Fréger, P., Castel, H. and Proust F.: Superior interhemispheric approach for midline meningioma from the anterior and middle cranial base. J. Neurosur. 57:105-113 (2011). (IF 2.9)
  13. Genty, S., Derrey, S., Pouplin, S., Lefaucheur, R., Chastan, N., Gérardin, E. and Maltête, D.: Pain due to steoarthritis may impair the early outcome of deep brain stimulation in Parkinson's disease. Clin. Neurol. Neurosurg. 113:864-867 (2011). (IF 1.6) Specific clinical report
  14. Godefroy A., Derrey S., Laquerriere A., Perot G., Proust F. and Gerardin E. Perfusion MR imaging and MR spectroscopy of gemistocytic astrocytoma. J. Neuroradiol. 39:190-194 (2011). (IF 1.2) Specific clinical report
  15. Nafeh, S., Danielou, E., Calenda, E., Compère, V. and Dureuil, B.: Fiberoptic tracheal intubation through a Boussignac valve to maintain continuous oxygenation during intubation in severely obese patients: 11 cases. J. Clin. Anesth. 23:345-346 (2011). (IF 1.2) Specific clinical report
  16. Clavier, T., Compère, V., Hibon, R., Hamou-Plotkine, L. and Dureuil, B.: Lingual tonsil hypertrophy and unanticipated difficult airway management. Ann. Fr. Anesth. Reanim. 30:375-376 (2011). (IF 0.8) Specific clinical report
  17. Lemarie, M., Compère, V., Fourdrinier, V., Lignot, S., Legrand, L., Marguerite, C., Devellenne, C., Wood, G., Dujardin, F. and Dureuil, B.: Prescription analgesic during the anaesthesia consultation on the incidence of postoperative pain at home in ambulatory orthopaedic surgery. Ann. Fr. Anesth. Reanim. 30:883-887 (2011). (IF 0.8) Specific clinical report
  18. Girszyn, N., Fares, J., Proust, F., Héron, F., Marie, I., Lévesque, H. and Kaminsky, P.: Chronic headache in a 37-year-old woman. Rev. Med. Interne. 32:770-772 (2011). (IF 0.6) Specific clinical report
  19. Levêque, S., Derrey, S., Martinaud, O., Gérardin, E., Langlois, O., Fréger, P., Hannequin, D., Castel, H. and Proust, F.: Superior interhemispheric approach for midline meningioma from the anterior cranial base. Neurochirurgie 57:105-113 (2011). (IF 0.3) Specific clinical report

- 2010 -

  1. Jarry, M., Diallo, M., Lecointre C., Desrues, L., Tokay, T., Chatenet, D., Leprince, J., Rossi, O., Vaudry, H., Tonon, M.C., Prézeau, L., Castel, H. and Gandolfo, P.: The vasoactive peptides UII and URP regulate astrocyte activity through common and distinct mechanisms. Involvement in cell proliferation. Biochem. J. 428:113-124 (2010). (IF 5.6)
  2. Klein, D.C., Bailey, M.J., Carter, D.A., Kim, J.S., Shi, Q., Ho, A.K., Chik, C.L., Gaildrat, P., Morin, F., Ganguly, S., Rath, M.F., Moller, M., Sugden, D., Rangel, Z.G., Munson, P.J., Weller, J.L. and Coon, S.L.: Pineal function: impact of microarray analysis. Mol. Cell. Endocrinol. 314:170-83 (2010). (IF 4.1)
  3. Maltete, D., Bellien, J., Cabrejo, L., Iacob, M., Proust, F., Mihout, B., Thuillez, C., Guegan-Massardier, E. and Joannides, R.: Hypertrophic remodeling and increased arterial stiffness in patients with intracranial aneurysms. Atherosclerosis 211:486-491 (2010). (IF 4.1)
  4. Compère, V., Lanfray, D., Castel, H., Morin, F., Leprince, J., Dureuil, B., Vaudry, H., Pelletier, G. and Tonon, M.C.: Acute food deprivation reduces expression of diazepam-binding inhibitor, the precursor of the anorexigenic octadecaneuropeptide ODN, in mouse glial cells. J. Mol. Endocrinol. 44:295-299 (2010). (IF 3.6)
  5. Nakano, M., Minagawa, A., Hasunuma, I., Okada, R., Tonon, M.C., Vaudry, H., Yamamoto, K., Kikuyama, S., Machida, T. and Kobayashi, T.: D2 dopamine receptor subtype mediates the inhibitory effect of dopamine on TRH-induced prolactin release from the bullfrog pituitary. Gen. Comp. Endocrinol. 168:287-292 (2010). (IF 3.1)
  6. Matsuda, K., Kojima, K., Wada, K., Maruyama, K., Leprince, J., Tonon, M.C., Uchiyama, M. and Vaudry, H. : The anorexigenic action of the octadecaneuropeptide ODN in goldfish is mediated through the MC4R- and subsequently the CRF receptor-signaling pathways. J. Mol. Neurosci. 42:74-79 (2010). (IF 2.9)
  7. Vaudry, H., Do Rego J.C., Le Mevel, J.C., Chatenet, D., Tostivint, H., Fournier, A., Tonon, M.C., Pelletier, G., Conlon, J.M. and Leprince, J.: Urotensin II, from fish to human. Ann. N.Y. Acad. Sci. 1200:53-66 (2010). (IF 2.9) Review
  8. Derrey, S., Lefaucheur, R., Chastan, N., Gérardin, E., Hannequin, D., Desbordes, M. and Maltete, D.: Alleviation of off-period dystonia in Parkinson disease by a microlesion following subthalamic implantation. J. Neurosurg. 112:1263-1266 (2010). (IF 2.7)
  9. Proust, F., Gerardin, E., Derrey, S., Lesveque, S., Ramos, S., Langlois, O., Tollard, E., Benichou, J., Chassagne, P., Clavier, E. and Freger, P.: Interdisciplinary treatment of ruptured cerebral aneurysms in elderly patients. J. Neurosurg. 112:1200-1207 (2010). (IF 2.7)
  10. Mrabet Khiari, H., Khemiri, E., Parain, D., Hattab, N., Proust, F. and Mrabet, A.: Epilepsy surgery program in Tunisia: an example of a Tunisian French collaboration. Seizure – Eur. J. Epilep. 19:74-78 (2010). (IF 1.6) Specific clinical report
  11. Gérardin, E., Tollard, E., Derrey, S., Langlois, O., Dacher, J.N., Douvrin, F., Fréger, P. and Proust, F.: Usefulness of multislice computerized tomographic angiography in the postoperative evaluation of patients with clipped aneurysms. Acta Neurochir. 152:793-802 (2010). (IF 1.4) Specific clinical report
  12. Demars, N., Compère, V., Duparc, F., Fourdrinier, V. and Dureuil, B.: Contribution of the anatomy laboratory to the practical training of residents in regional anesthesia. Surg. Radiol. Anat. 32:69-73 (2010). (IF 0.8) Specific clinical report
  13. Michot, J.B., Compère, V., Hardy, H. and Dureuil, B.: Temporomandibular joint dislocation occurring by removing an LMA. Ann. Fr. Anesth. Reanim. 29:738-739 (2010). (IF 0.8) Specific clinical report
  14. Proust, F., Bracard, S., Thines, L., Leclerc, X., Penchet, G., Bergé, J., Vignes, J.R., Irthum, B., Gabrillargues, J., Chazal, J., Bataille, B., Drouinau, J., Mourier, K., Ricolfi, F., Gay, E., Bessou, P., Lonjon, M., Sedat, J., David, P., Lajaunias, P., Morandi, X., Gauvrit, J.Y., Pelissou, I., Turjman, F., Roche, P.H., Dufour, H., Levrier, O., Emery, E., Courthéoux, P., Laguarrigue, J., Cognard, C., Civit, T., Lejeune, J.P.: Aneurismal subarachnoid hemorrhage in the elderly subject. Should this patient participate in a randomized clinical trial? Neurochirurgie 56:67-72 (2010). (IF 0.4) Specific clinical report

- 2009 -

  1. Do-Rego, J.L., Seong, J.Y., Burel, D., Leprince, J., Luu-The, V., Tsutsui, K., Tonon, M.C., Pelletier, G. and Vaudry, H.: Neurosteroid biosynthesis in vertebrates: enzymatic pathways and neuroendocrine regulation. Front. Neuroendocrinol. 30:259-301 (2009). (IF 12.1) review
  2. Bailey, M.J., Coon, S.L., Carter, D.A., Humphries, A., Kim J.S., Shi, Q., Gaildrat, P., Morin, F., Ganguly, S., Hogenesch, J.B., Weller, J.L., Rath, M.F., Møller, M., Baler, R., Sugden, D., Rangel, Z.G., Munson, P.J., Klein, D.C. : Night/day changes in pineal expression of >600 genes: central role of adrenergic/cAMP signaling. J. Biol. Chem. 284:7606-7622 (2009). (IF 5.3)
  3. Gutiérrez-Pascual, E., Leprince, J., Martinez-Fuentes, A.J., Ségalas-Milazzo, I., Pineda, R., Roa, J., Duran-Prado, M., Guilhaudis, L., Desperrois, E., Lebreton, A., Pinilla, L., Tonon, M.C., Malagon, M.M., Vaudry, H., Tena-Sempere, M. and Castano, J.P.: In vivo and in vitro structure-activity relationships and strucutral conformation of kisspeptin-10-related peptides. Mol. Pharmacol. 76:58-67 (2009). (IF 4.5)
  4. Lefebvre, T., Gonzalez, B.J., Vaudry, D., Desrues, L., Falluel-Morel, A., Aubert, N., Fournier, A., Tonon, M.C., Vaudry, H. and Castel, H.: Paradoxical effect of ethanol on potassium channels currents and cell survival in cerebellar granule neurons. J. Neurochem. 110:976-989 (2009). (IF 4.8)
  5. Compère, V., Legrand, J.F., Guitard, P.G., Azougagh, K., Baert, O., Ouennich, A., Fourdrinier, V., Frebourg, N. and Dureuil, B.: Bacterial colonization after tunneling in 402 perineural catheters: a prospective study. Anesth. Analg. 108:1326-1330 (2009). (IF 3.1)
  6. Oppenheim, C., Naggara, O., Touze, E., Lacour, J. C., Schmitt, E., Bonneville, F., Crozier, S., Guegan-Massardier, E., Gerardin, E., Leclerc, X., Neau, J. P., Sirol, M., Toussaint, J. F., Mas, J. L. and Meder, J. F.: High-resolution MR imaging of the cervical arterial wall: what the radiologist needs to know. Radiographics 29:1413-1431 (2009). (IF 2.8)
  7. Do-Rego, J.L., Seong J.Y., Burel D., Luu-The V., Larhammar D., Tsutsui K., Pelletier G., Tonon, M.C. and Vaudry, H. : Steroid biosynthesis within the frog brain: a model of neuroendocrine regulation. Ann. N.Y. Acad. Sci. 1163:83-92 (2009). (IF 2.7) Review
  8. Galas, L., Raoult, E., Tonon, M.C., Okada, R., Jenks, B.G., Castaño, J.P., Kikuyama, S., Malagon, M., Roubos, E.W. and Vaudry, H.: TRH acts as a multifunctional hypophysiotropic factor in vertebrates. Gen. Comp. Endocrinol. 164:46-50 (2009). (IF 2.7) Review
  9. Proust, F., Martinaud, O., Gerardin, E., Derrey, S., Leveque, S., Bioux, S., Tollard, E., Clavier, E., Langlois, O., Godefroy, O., Hannequin, D. and Freger, P.: Quality of life and brain damage after microsurgical clip occlusion or endovascular coil embolization for ruptured anterior communicating artery aneurysms: neuropsychological assessment. J. Neurosurg. 110:19-29 (2009). (IF 2.6)
  10. Martinaud, O., Perin, B., Gerardin, E., Proust, F., Bioux, S., Gars, D. L., Hannequin, D. and Godefroy, O.: Anatomy of executive deficit following ruptured anterior communicating artery aneurysm. Eur. J. Neurol. 16:595-601 (2009). (IF 2.5)
  11. Compère, V., Rey, N., Baert, O., Ouennich, A., Fourdrinier, V., Rossignol, X., Beccari, R. and Dureuil, B.: Major complications after 400 continuous popliteal sciatic nerve blocks for post-operative analgesia. Acta Anaesthesiol. Scand. 53:339-345 (2009). (IF 2.3)
  12. Gerardin, E., Daumas-Duport, B., Tollard, E., Langlois, O., Dacher, J.N., Clavier, E. and Proust, F. : Usefulness of multislice computerized tomography angiography in preoperative diagnosis of ruptured cerebral aneurysms. J. Neuroradiol. 36:278-84 (2009). (IF 1.2) Specific clinical report
  13. Thery-Langlois, C., Amossé, C., Lefaucheur, R., Bioux, S., Gérardin, E., Hannequin, D. and Martinaud, O.: An aphasic reader. Rev. Neurol. (Paris) 165:601-604 (2009). (IF 0.9) Specific clinical report
  14. Fekhkhar, K., Rachet, B., Gillet, R., Provost, D., Lalo, J.P., Rieu, M., Compère, V., Roussel, F., Marpeau, L. and Dureuil, B.: Amniotic fluid embolism during curettage for a pregnancy arrest. Case report.  Ann. Fr. Anesth. Reanim. 28:795-798(2009). (IF 0.8) Specific clinical report
  15. Marguerite, C., Provost, D., Compère, V., Jean, J. and Dureuil, B.: False capillary hyperglycaemia and true iatrogenic postoperative hypoglycaemia. Ann. Fr. Anesth. Reanim.  28:704-705 (2009). (IF 0.8) Specific clinical report
  16. Ould Slimane, M., Foulongne, E., Derrey, S., Fréger, P. and Proust, F.: [Polyostotic fibrous dysplasia of the thoracic spine. A case study and review of the literature]. Neurochirurgie 55:595-599 (2009). (IF 0.5) Review
  17. Derrey, S., Maltete, D., Ahtoy, P., Fregey, P. and Proust, F.: [Severe orthostatic hypotension and intramedullary tumor: a case report and review of the literature]. Neurochirurgie 55:589-594 (2009). (IF 0.5) Review

- 2008 -

  1. Tokay, T., Hachem, R., Masmoudi-Kouki, O., Gandolfo, P., Desrues, L., Leprince, J., Castel, H., Diallo, M., Amri, M., Vaudry, H. and Tonon, M.C.: Beta-amyloid peptide stimulates endozepine release in cultured rat astrocytes through activation of N-formyl peptide receptors. Glia 56:1380-1389 (2008). (IF 5.6)
  2. Maltete, D., Derrey, S., Chastan, N., Debono, B., Gérardin, E., Freger, P., Mihout, B., Menard, J.F. and Hannequin, D.: Microsubthalamotomy: an immediate predictor of long-term subthalamic stimulation efficacy in Parkinson disease. Mov. Disord. 23:1047-1050 (2008). (IF 3.9)
  3. Desrues, L., Lefebvre, T., Diallo, M., Gandolfo, P., Leprince, J., Chatenet, D., Vaudry, H., Tonon, M.C. and Castel, H.: Effect of GABAA receptor activation on UT-coupled signaling pathways in rat cortical astrocytes. Peptides 29:727-734 (2008). (IF 2.6)
  4. Diallo, M., Jarry, M., Desrues, L., Castel, H., Chatenet, D., Leprince, J., Vaudry, H., Tonon, M.C. and Gandolfo, P.: [Orn5]URP acts as a pure antagonist of urotensinergic receptors in rat cortical astrocytes. Peptides 29:813-819 (2008). (IF 2.6)
  5. Malagon, M.M., Molina, M., Gahete, M.D., Duràn-Prado, M., Martinez-Fuentes, A.J., Alcain, F.J., Tonon, M.C., Leprince, J., Vaudry, H., Castano, J.P. and Vásquez-Martinez, R.: Urotensin II and urotensin II-related peptide activate somatostatin receptor subtype 2 and 5. Peptides 29:711-720 (2008). (IF 2.6)
  6. Leprince, J., Chatenet, D., Dubessy, C., Fournier, A., Pfeiffer, B., Scalbert, E., Renard, P., Pacaud, P., Oulyadi, H., Ségalas-Milazzo, I., Guilhaudis, L., Davoust, D., Tonon, M.C. and Vaudry, H.: Structure-activity relationships of urotensin II and URP. Peptides 29:658-673 (2008). Review (IF 2.6)
  7. Derrey, S., Maltête, D., Chastan, N., Debono, B., Proust, F., Gérardin, E., Weber, J., Mihout, B. and Fréger, P.: Deep brain stimulation of the subthalamic nucleus in Parkinson's disease: usefulness of intraoperative radiological guidance. The Stereoplan. Stereotact. Funct. Neurosurg. 86:351-358 (2008). (IF 1.5) Specific clinical report
  8. Modzelewski R., de la Rue, T., Janvresse, E., Hitzel, A., Menard, J.F., Manrique, A., Gardin, I., Gérardin, E., Hannequin, D. and Vera, P.: Development and validation of the random walk algorithm: application to the classification of diffuse heterogeneity in brain SPECT perfusion Images. J. Comput. Assist. Tomogr. 32:651-659 (2008). Specific clinical report(IF 1.5)
  9. Jean, J., Compère, V., Fourdrinier, V., Marguerite, C., Auquit-Auckbur, I., Milliez, P.Y. and Dureuil, B.: Risk of pulmonary aspiration in patients after weight loss due to bariatric surgery. Anesth. Analg. 107:1257-1259 (2008). (IF 1.3) Specific clinical report
  10. Oppenheim, C ., Touzé, E., Leclerc, X., Schmitt, E., Bonneville, F., Vandermarcq, P., Gérardin, E., Toussaint, J.F., Mas, J.L. and Méder, JF.: High resolution MRI of carotid atherosclerosis: looking beyond the arterial lumen. J. Radiol. 89:293-301 (2008). (IF 0.7) Specific clinical report
  11. Proust, F., Gérardin,  E. and Chazal, J.: Unruptured intracranial aneurysm and microsurgical exclusion: the need of a randomized study of surgery versus natural history. J. Neuroradiol. 35:109-115 (2008). Specific clinical report (IF 0.7)
  12. Richard, J.A., Raymond, J., Guillemin, F., Proust, F., Molyneux, A. J., Fox, A. J., Claiborne, J. S., Meder, J. F. and Rouleau, I.: Unruptured Intracranial Aneurysms. A critical review of the international study of unruptured intracranial aneurysms (ISUIA) and of appropriate methods to address the clinical problem. Interv. Neuroradiol. 14:85-96 (2008). Review
    (IF 0.2)