Research team website  

Tel: (33)2-35-14-66-28 - ORCID : https://orcid.org/0000-0003-3081-1798
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Nationality: French
Current position: Assistant Professor (Maître de conférences), Laboratory of Neuronal and Neuroendocrine Communication and Differentiation (DC2N), team « Astrocyte and Vascular Niche ». DC2N. http://dc2n.labos.univ-rouen.fr/index.php/equipe-3

Biography

Oana Chever is a neurophysiologist, interested in neuronal excitability modulation in physiological and physiopathological states. She started working on cerebral ionic homeostasis during her Ph.D under the supervision of Dr. F. Amzica at Laval University (Québec, Canada), with who she worked on potassium buffering and astrocytes. In 2009, she joined the team headed by N. Rouach (CIRB, Collège de France, Paris) to study the role of astrocytes and astrocytic network on neuronal activities and excitability. From 2014 to 2017, she joined the laboratory of Dr. M. Mantegazza to study the role of interneurons in neuronal network excitability and migraine ethiology. 
Oana Chever has an expertise in electrophysiology and optogenetics, both ex vivo and in vivo. She is currently teaching in Neurosciences and Physiology at the University of Rouen. She’s also working on glioma invasion and neuronal excitability in the team « Astrocytes and Vascular Niche” (DC2N, team leader : Dr Hélène Castel).

Education-Position

2004-2008  PhD Thesis in Neurobiology, Laval University, Quebec Canada. Laboratory of Neurophysiology, CRULRG.  Supervisor : Pr. Florin Amzica.
2009-2014 Post-Doctoral position, CIRB, Collège de France, Paris.  Laboratory of  Neuroglial Interactions in Cerebral Physiopathology  (Head : Dr. Nathalie Rouach). 
2014-2017 Post-Doctoral position, IPMC, UMR7275 CNRS Université Nice Côte d’Azur, Valbonne-Sophia Antipolis. Laboratory of Molecular and Cellular Pathophysiology of Voltage-gated Na+ Channel and Neuronal Excitability (Head : Dr. Massimo Mantegazza).

Main Contributions publications

  1. Chinigò, G., Castel, H., Chever, O. and Gkika, D.: TRP Channels in Brain Tumors. Front. Cell Dev. Biol. Doi: 10.3389/fcell.2021.617801 (2021)
  2. Cohen-Salmon, M., Slaoui, L., Mazaré, N., Gilbert, A., Oudart, M., Alvear-Perez,  R., Elorza-Vidal, X., Chever, O. and Boulay, A.C. : Astrocytes in the regulation of cerebrovascular functions. Glia Doi: 10.1002/glia.23924. (2020)
  3. Zerimech,  S. , Chever, O., Scalmani, P. ,Pizzamiglio, P., Duprat, F. and Mantegazza, M. : Cholinergic modulation inhibits cortical spreading depression in mouse neocortex through activation of muscarinic receptors and decreased excitatory/inhibitory drive. Neuropharmacology Doi: 10.1016/j.neuropharm.2020.107951 (2020) 
  4. Dossi, E., Blauwblomme, T., Moulard, J., Chever, O., Vasile, F., Guinard, E., Le Bert, M., Couillin, I., Pallud, J., Capelle, L., Huberfeld, G. and Rouach, N. : Pannexin-1 channels contribute to seizure generation in human epileptic brain tissue and in a mouse model of epilepsy. Sci. Transl. Med. doi:10.1126/scitranslmed.aar3796 (2018)
  5. Chever, O., Dossi, E. et  Rouach, N. : Contrôle astroglial de la synchronisation neuronale : " mind the GAP!". Méd. Sci. (Paris) 32:820-822 (2016).
  6. Chever, O., Dossi, E., Pannasch, U., Derangeon, M. and Rouach, N. : Astroglial networks promote neuronal coordination. Sci. Signal.  doi:10.1126/scisignal.aad3066 (2016).
  7. Chever, O., Pannasch, U., Ezan, P. and Rouach, N. : Astroglial connexin 43 sustains glutamatergic synaptic efficacy. Philos. Trans. R Soc. Lond. B Biol. Sci. doi: 10.1098/rstb.2013.0596 (2014). NCBI
  8. Chever, O., Lee, C.Y. and Rouach, N. : Astroglial connexin43 hemichannels tune basal excitatory synaptic transmission. J. Neurosci. 34:11228-11232 (2014). NCBI
  9. Dallérac, G., Chever, O. and Rouach, N. : How do astrocytes shape synaptic transmission? Insights from electrophysiology. Front. Cell. Neurosci. doi: 10.3389/fncel.2013.00159 (2013). Review. NCBI
  10. Chever, O., Djukic, B., McCarthy, K.D. and Amzica, F. : Implication of Kir4.1 channel in excess potassium clearance: an in vivo study on anesthetized glial-conditional Kir4.1 knock-out mice. J. Neurosci. 30:15769-15777 (2010). NCBI

 
Grants

  • FEDER Funding - RIN Emergent 2020 (146 000 euros). "Regulation of glioma invasion in white matter by axonal activity"
  • Cancéropole Nord Ouest, Support for "Emerging Projects" 2021 (20 000 euros). "Implementation of in vivo photometry for the study of neuron-glioma cell interactions"