FR/EN

REGULATION DE LA NEUROGENESE DEVELOPPEMENTALE

 

 

Formation

  • Master en Neuroscience, Université de Rouen, France, 2001
  • Doctorat en Neuroscience, Université de Rouen, France, 2005
  • Post-Doctorat, Department of Neuroscience and Cell Biology, Rutgers Robert Wood Johnson Medical School, Piscataway, NJ USA (Laboratoire du Pr. Emanuel DiCiccoBloom), 2005-08
  • Post-Doctorat, Laboratoire de Différenciation Cellulaire et Moléculaire, Université de Rouen, France (Equipe du Dr David Vaudry), 2008-09

 

Titulaire du Niveau I en expérimentation animale et formé à la chirurgie du petit animal.

Coordonnées

Inserm U1239 – DC2N
CURIB
2ème étage, Bureau 239
25, rue Tesnière
76821 Mont-Saint-Aignan
Telephone: +33(0)235 14 6641
Fax: +33(0)235 14 6946
E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

 

 

Responsabilités pédagogiques:

-          Responsable du M1 Biologie Santé - Imagerie Cellulaire

-          Responsable de Première année de la Spécialité Technologies du Vivant à l’école d’ingénieur-e-s ESITEch

Domaine de recherche: Mécanismes contrôlant la survie et la différenciation neuronale, et conséquences sur la formation de réseaux fonctionnels

 

Activités de recherche

Une grande partie des troubles du développement trouve son origine au niveau d’anomalies de la neurotransmission, de la connectivité neuronale et/ou des interactions neurone/glie. Il est donc essentiel de comprendre les mécanismes cellulaires impliqués dans la mise en place des réseaux neuronaux, notamment corticaux, afin de proposer de nouvelles approches thérapeutiques ou de nouveaux marqueurs et ainsi de prévenir la survenue de ces déficits. Notre groupe s’intéresse en particulier à l’étude du rôle de la Sélénoprotéine T au cours du neurodéveloppement, et à la contribution des mécanismes régulant l’homéostasie redox dans la mise en place des circuits neuronaux fonctionnels. La Sélénoprotéine T est une protéine à Sélénium, identifiée au laboratoire comme exprimée dans le système nerveux en cours de développement. Au moyen de modèles d’invalidation génétique chez la souris, nous avons mis en évidence un rôle de cette protéine dans le contrôle de l’homéostasie redox et dans la survie des neurones immatures. Ces altérations conduisent à des modifications comportementales, en absence d’anomalies morphologiques.

L’utilisation de ces modèles murins, ainsi que des approches plus ciblées, telles que l’électroporation in utero vont nous permettre d’approfondir la compréhension des mécanismes impliqués dans la mise en place des fonctions cognitives et leurs altérations lors de contextes physiopathologiques tels que les troubles apparentés à l’autisme (ASD) ou les troubles du déficit de l’attention avec/sans hyperactivité (ADHD).

        

 

Publications

DiCicco-Bloom, E., Falluel-Morel,A., Developmental Neurogenesis, in : Reference Module in Neuroscience and Biobehavioral Psychology. Elsevier, ISBN 9780128093245 in press.

Castex, M.T., Arabo, A., Bénard, M., Roy, V., Le Joncour, V., Prévost, G., Bonnet, J.-J., Anouar, Y., Falluel-Morel, A., 2015. Selenoprotein T Deficiency Leads to Neurodevelopmental Abnormalities and Hyperactive Behavior in Mice. Mol. Neurobiol. 53:5818-5832

Boukhzar, L., Hamieh, A., Cartier, D., Tanguy, Y., Alsharif, I., Castex, M., Arabo, A., El Hajji, S., Bonnet, J.-J., Errami, M., Falluel-Morel, A., Chagraoui, A., Lihrmann, I., Anouar, Y., 2016. Selenoprotein T Exerts an Essential Oxidoreductase Activity That Protects Dopaminergic Neurons in Mouse Models of Parkinson’s Disease. Antioxid. Redox Signal. 24, 557–574.

Balland, E., Dam, J., Langlet, F., Caron, E., Steculorum, S., Messina, A., Rasika, S., Falluel-Morel, A., Anouar, Y., Dehouck, B., Trinquet, E., Jockers, R., Bouret, S.G., Prévot, V., 2014. Hypothalamic tanycytes are an ERK-gated conduit for leptin into the brain. Cell Metab. 19, 293–301.

Petit, A., Delaune, A., Falluel-Morel, A., Goullé, J.-P., Vannier, J.-P., Dubus, I., Vasse, M., 2013. Importance of ERK activation in As2O3-induced differentiation and promyelocytic leukemia nuclear bodies formation in neuroblastoma cells. Pharmacol. Res. 77, 11–21.

Prevost, G., Arabo, A., Jian, L., Quelennec, E., Cartier, D., Hassan, S., Falluel-Morel, A., Tanguy, Y., Gargani, S., Lihrmann, I., Kerr-Conte, J., Lefebvre, H., Pattou, F., Anouar, Y., 2013. The PACAP-regulated gene selenoprotein T is abundantly expressed in mouse and human β-cells and its targeted inactivation impairs glucose tolerance. Endocrinology 154, 3796–3806.

Falluel-Morel, A., Lin, L., Sokolowski, K., McCandlish, E., Buckley, B., DiCicco-Bloom, E., 2012. N-acetyl cysteine treatment reduces mercury-induced neurotoxicity in the developing rat hippocampus. J. Neurosci. Res. 90, 743–750.

Sokolowski, K., Falluel-Morel, A., Zhou, X., DiCicco-Bloom, E., 2011. Methylmercury (MeHg) elicits mitochondrial-dependent apoptosis in developing hippocampus and acts at low exposures. Neurotoxicology 32, 535–544.

Tanguy, Y., Falluel-Morel, A., Arthaud, S., Boukhzar, L., Manecka, D.-L., Chagraoui, A., Prevost, G., Elias, S., Dorval-Coiffec, I., Lesage, J., Vieau, D., Lihrmann, I., Jégou, B., Anouar, Y., 2011. The PACAP-regulated gene selenoprotein T is highly induced in nervous, endocrine, and metabolic tissues during ontogenetic and regenerative processes. Endocrinology 152, 4322–4335.

DiCicco-Bloom, E., Falluel-Morel, A., 2010. Developmental Neurogenesis, in: Encyclopedia of Behavioral Neuroscience. Elsevier, pp. 396–404.

 

Financements

            

 

Membres du groupe

  •   Anthony Falluel-Morel, Maître de conférences
  •   Emmanuelle Carpentier, M2 Neuroscience

 

Alumni

  •   Lisa Brunet, M2 Neurosciences, actuellement en Doctorat à l’Université de Rouen
  •   Valentin Vanhee, M2 Neurosciences, actuellement au CiToxLAB (Evreux, France)
  •   Francesca Trentin,  M2 Biologie Cellulaire, actuellement à l’Hôpital Parini (Aoste, Italie)
  •   Benoît Dechelotte, M1 Médecine, actuellement interne (Lyon, France)
  •   Melody Atkins, élève ingénieure, actuellement en Doctorat à l’UPMC (Paris, France)
  •   Matthieu Castex, Doctorant, actuellement au Lycée G. Brassens (Neufchâtel-en-Braye, France)
  •   Audrey Filézac de l’Etang, M1 Neurosciences, actuellement en post-doctorat à Genentech (San Francisco, USA)
  •   Yannick Tanguy, Doctorant, actuellement à la Fondation IPSEN (Paris, France)

 

 

 

 

 FR/EN

REGULATION OF DEVELOPMENTAL NEUROGENESIS

 

 

Education and Training

  • M.Sc. in Neuroscience, University of Rouen, France, 2001
  • Ph.D. in Neuroscience, University of Rouen, France, 2005
  • Post-Doctoral Fellow, Department of Neuroscience and Cell Biology, Rutgers Robert Wood Johnson Medical School, Piscataway, NJ USA (Emanuel DiCiccoBloom's lab), 2005-08
  • Post-Doctoral Fellow, Laboratory of Cellular and Neuroendocrine Differenciation, University of Rouen, France (David Vaudry's lab), 2008-09

Holder of a Level I training in animal experimentation and trained on small mammal surgery.

Contact Information

Inserm U1239 – DC2N
CURIB Building
2nd floor, room 239
25, rue Tesnière
76821 Mont-Saint-Aignan
Telephone: +33(0)235 14 6641
Fax: +33(0)235 14 6946
E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

 

 

 

Educational role:

 

-          Responsible of  Master 1 Biology & Health - Cell Imaging

-          Responsible of the 1st year in Life Technologies at ESITEch Engineering School

 

Research Areas: Mechanisms controlling neuronal fate and survival, brain wiring and function

 

Research

 

Many developmental disorders arise from abnormalities in neurotransmission, neuronal connectivity, and/or neuron/glia interactions. It is thus essential to elucidate the mechanisms underlying the establishment of neuronal networks, including cortical network, to propose new therapies or markers aiming at preventing the occurrence of such brain deficits in childs. Our group is focused on the function of Selenoprotein T during neurodevelopment, and its contribution to the regulation of redox homeostasis during the establishment of functional circuitry.

 

Our research unit has characterized Selenoprotein T as a Selenium-containing protein expressed in the central nervous system during development. Using genetic invalidation models in mice, we have demonstrated that this protein contributes to the control of redox homeostasis and neuroblast survival. These alterations detected in the knockout animals lead to behavioral deficits, which manifest in the absence of gross morphological abnormalities.

 

Murine models, supplemented with more specific approaches, such as in utero electroporation are being used to contribute deciphering the mechanisms underlying the complex origin of cognitive functions, and how they can be altered during pathophysiological conditions, such as ASD or ADHD.

 

        

 

Selected Publications

DiCicco-Bloom, E., Falluel-Morel,A., Developmental Neurogenesis, in : Reference Module in Neuroscience and Biobehavioral Psychology. Elsevier, ISBN 9780128093245 in press.

Castex, M.T., Arabo, A., Bénard, M., Roy, V., Le Joncour, V., Prévost, G., Bonnet, J.-J., Anouar, Y., Falluel-Morel, A., 2015. Selenoprotein T Deficiency Leads to Neurodevelopmental Abnormalities and Hyperactive Behavior in Mice. Mol. Neurobiol. 53:5818-5832

Boukhzar, L., Hamieh, A., Cartier, D., Tanguy, Y., Alsharif, I., Castex, M., Arabo, A., El Hajji, S., Bonnet, J.-J., Errami, M., Falluel-Morel, A., Chagraoui, A., Lihrmann, I., Anouar, Y., 2016. Selenoprotein T Exerts an Essential Oxidoreductase Activity That Protects Dopaminergic Neurons in Mouse Models of Parkinson’s Disease. Antioxid. Redox Signal. 24, 557–574.

Balland, E., Dam, J., Langlet, F., Caron, E., Steculorum, S., Messina, A., Rasika, S., Falluel-Morel, A., Anouar, Y., Dehouck, B., Trinquet, E., Jockers, R., Bouret, S.G., Prévot, V., 2014. Hypothalamic tanycytes are an ERK-gated conduit for leptin into the brain. Cell Metab. 19, 293–301.

Petit, A., Delaune, A., Falluel-Morel, A., Goullé, J.-P., Vannier, J.-P., Dubus, I., Vasse, M., 2013. Importance of ERK activation in As2O3-induced differentiation and promyelocytic leukemia nuclear bodies formation in neuroblastoma cells. Pharmacol. Res. 77, 11–21.

Prevost, G., Arabo, A., Jian, L., Quelennec, E., Cartier, D., Hassan, S., Falluel-Morel, A., Tanguy, Y., Gargani, S., Lihrmann, I., Kerr-Conte, J., Lefebvre, H., Pattou, F., Anouar, Y., 2013. The PACAP-regulated gene selenoprotein T is abundantly expressed in mouse and human β-cells and its targeted inactivation impairs glucose tolerance. Endocrinology 154, 3796–3806.

Falluel-Morel, A., Lin, L., Sokolowski, K., McCandlish, E., Buckley, B., DiCicco-Bloom, E., 2012. N-acetyl cysteine treatment reduces mercury-induced neurotoxicity in the developing rat hippocampus. J. Neurosci. Res. 90, 743–750.

Sokolowski, K., Falluel-Morel, A., Zhou, X., DiCicco-Bloom, E., 2011. Methylmercury (MeHg) elicits mitochondrial-dependent apoptosis in developing hippocampus and acts at low exposures. Neurotoxicology 32, 535–544.

Tanguy, Y., Falluel-Morel, A., Arthaud, S., Boukhzar, L., Manecka, D.-L., Chagraoui, A., Prevost, G., Elias, S., Dorval-Coiffec, I., Lesage, J., Vieau, D., Lihrmann, I., Jégou, B., Anouar, Y., 2011. The PACAP-regulated gene selenoprotein T is highly induced in nervous, endocrine, and metabolic tissues during ontogenetic and regenerative processes. Endocrinology 152, 4322–4335.

DiCicco-Bloom, E., Falluel-Morel, A., 2010. Developmental Neurogenesis, in: Encyclopedia of Behavioral Neuroscience. Elsevier, pp. 396–404.

 

Funding