"Effets de l'alcoolisation aigüe (binge drinking) sur le cerveau de l'adolescent", par David Vaudry



On behalf of the International Regulatory Peptide Society, the Summer Neuropeptide Conferences, the European Neuropeptide Club and the Groupe Français des Peptides et des Protéines, we would like to invite you to participate to RegPep2016 that will be held in Rouen (Normandy, France) from July 12th to 14th, 2016. The venue of RegPep2016 will be the Law Faculty, a beautiful new building located in downtown Rouen, on the bank of the Seine River, within walking distance from the Place du Vieux-Marché (where Joan of Arc was burnt alive in 1431) and the famous Cathedral, painted by Claude Monet.

The scientific program will comprise a Lay-public Lecture, 3 Plenary Lectures, 20 Symposia with 80 State-of-the-Art Lectures, 32 free oral communications selected from the abstracts, 12 communications from young investigators and 2 poster sessions.

Several sessions about the ‘Role of neuropeptides in the progression of tumours of the nervous system’, the ‘Therapeutic potential of the PACAP/VIP neuro-peptide family and related peptides in neurodegenerative and neuropsychiatric diseases’, the ‘Role of peptides in stress-related modulation of visceral pain’, ‘New insights on neuropeptides in obesity and metabolic disorders’, ‘Hypocretins/orexins in arousal, stress, reward and cognition’ and ‘Brain circuits underlying stress perception, response, and adaptation mediated and modulated by neuropeptides’ will contribute to a program which should be of broad in-terest for people working in Neurosciences. 

Sessions will address both basic and clinical issues. Participation of clinicians and private companies is encouraged. Basic research will also be well represented with some sessions addressing for instance evolutionary aspects. Attending RegPep2016, you will be able to learn about the most recent advances on peptides that regulate cell, tissue or organ functions in physiological or pathological conditions. For more information regarding the program, please visit the RegPep2016 website (

Besides the scientific program, the social events, included in the registration fee of all participants and accompanying persons, will comprise a get-together party on Tuesday July 12th, a visit of Rouen Impressionist Museum and a Banquet Dinner on Wednesday July 13th, and a visit of Rouen plus a firework display on the Seine River on Thursday July 14th. Travel awards for young investigators (graduate students and postdoctoral fellows) will be available. Satellite meetings will be organized before the RegPep2016 (July 11th) and an optional excursion to Etretat Alabaster coast will be proposed after the meeting (July 15th). We very much hope that you will be able to join us for this major international meeting on bioactive peptides in Rouen in 2016. During this meeting, you will meet old friends and colleagues, and initiate new relationships with others working in fields similar to your own.


Registrations are now open on the website with an attractive fee until January 31th, 2016 for early registration. If there is anything that we can do to help you attend the congress, please do not hesitate to contact us directly at This email address is being protected from spambots. You need JavaScript enabled to view it.


European Neuropeptide Club

On the occasion of the European Neuropeptide Club’s annual congress which took place in Aberdeen (Scotland) from September 28th to October 1st, 2015, Dr David VAUDRY (Inserm U982) was invited to give a lecture entitled ‘How to improve PACAP efficiency for neuroprotection and neurorepair?’.



21st meeting of the European Society for Neurochemistry During the 21st meeting of the European Society for Neurochemistry, which took place in Tartu, Estonia, Dr David VAUDRY was invited to give a lecture entitled ‘Characterization of neuropeptides which control cerebellar granule cell survival, migration and différentiation’.



Final meeting of the PeReNE project

 The final meeting of PERENE project was held in Le Havre January 15th and 16th, 2015. On this occasion, the French and British researchers from the different teams of PERENE network have presented their work on peptide research through oral or posters presentations. Three plenary lectures were also given by Pr Heinrich Dircksen (Stockholm University, Stockholm, Suède) « Bioactive peptide in arthropods », Dr Nathalie Thiriet (INSERM U1084, Poitiers) « Protective and proliferative functions of NPY within the brain »and Dr Angelita   Rebollo (UPMC,  Paris) « Enhanced serum proteolysis resitance of cell-penetrating peptides ». Prizes were awarded at the end of the presentations. A prize for the best oral communication was given to Pierre-Michaël COLY for his presentation entitled « GPCR-Induced chemotactic migration requires mitigation of autophagy: involvement in glial cell invasion ».  Another award for best oral communication was won by Carla DELEPE, Elke HAENSELE, Nawel MELE, Marija MILJAK and Jana SOPKOVA-DE OLIVEIRA SANTOS for their presentation entitled « Cyclic peptide hormones: conformation, dynamics and pharmacophores of urotensin and vasopressin ».  The award for best poster was won by Seyma BAHDOUDI for her presentation entitled « The neuropeptide PACAP and the gliopeptide ODN prevent 6-hydroxydopamine-induced apoptosis of cerebellar granule neurons ».

This meeting was also the opportunity to organize the last Steering Committee of the PeReNE project.

19th GFPP Congress

The program and registration forms for the 19th GFPP congress (French Group for Peptides and Proteins) that will be held in Portbail (Manche, France) from May 17th to 22nd, 2015, are available at the following address:  This meeting will feature 13 invited lectures, 28 oral communications and several poster sessions. Requests for oral presentations and scholarships for students can still be sent to the Scientific Committee via the GFPP website until January 15th, 2015. Registration and abstract submissions can be made until January 30th, 2015.  For more information please contact  Jérôme LEPRINCE ( This email address is being protected from spambots. You need JavaScript enabled to view it. ).         

 Congress « Insights into neural stimulation and brain inflammation in stroke – from recovery mechanisms to targeted therapy 

Dr Olivier WURTZ (Inserm U982) will give a conference entitled « PACAP neuropeptide and brain stroke: Immunomodulation, keypoint of improved functional recovery » during the Congress « Insights into neural stimulation and brain inflammation in stroke – from recovery mechanisms to targeted therapy »  in Manchester (UK), November 12th to 14th, 2014.



Peptide meeting at the University of Rouen hematic Day on Peptides

  Researchers from the University of Rouen, in partnership with Cosmetic Valley cluster, Technopole CBS and GFPP, will organize a series of lectures on "Peptide delivery for therapeutic and cosmetic applications" at the Maison de l’Université, on the campus of Mont-Saint-Aignan, University of Rouen, on November 26th, 2014. This meeting will bring together international experts including Ijeoma UCHEGBU (Nanomerics) ‘Developing neuropeptide therapeutics-overcoming the blood brain barrier challenge’, Paolo BOTTI (Arisgen) ‘Non invasive administration of peptides’, Michel KHRESTCHATISKY (CNRS & Vect-Horus) ‘Development of peptide vectors for the delivery of drugs and imaging agents to different organs, notably the brain’, Joel RICHARD (Ipsen) ‘Peptide delivery: where do we stand and what does the future hold?’, Karl LINTNER (KAL'Idées) ‘Peptides and skin: ‘eppure penetrato!’ and ROGER NEW (Proxima concepts limited) ‘Peptide formulations for oral delivery’. Two additional oral presentations will be selected from submitted abstracts. Some posters will also be presented at lunch time and some visits of the PRIMACEN and PISSARO platforms will be proposed at the end of the day. Participation to this event is free but registration is mandatory before November 10th, 2014 at the following address: For further information, please contact David VAUDRY ( This email address is being protected from spambots. You need JavaScript enabled to view it. ) or Jerôme LEPRINCE (



During the 20th International Symposium on Regulatory Peptides that took place in Kyoto from September 7 to 10, 2014, Dr. David VAUDRY gave a lecture entitled "Characterization of PACAP neuroprotective effects and approaches for therapeutic applications."  During this conference, David VAUDRY was nominated to the Steering Committe of the International Regulatory Peptide Society ( Professor Jens Peter Goetze is now the new chairman of the RegPep society and Professor Schmidt Wolfgang, Editor-in-Chief of Regulatory peptides, has also joined the Steering Committe.


17th Annual meeting of the LARC-Neuroscience network


 The 17th annual meeting of the LARC-Neuroscience Network will be held on Friday October 25th, 2013, in Rouen. The deadline for registration and submission of abstracts is September 15th, 2013. For more information and to register, please visit the LARC-Neuroscience website at: To submit an abstract, go to:







Ms Hélène LACAILLE (INSERM U982) defended on June 18th, 2015, her PhD Thesis in une Thèse de Biologie Cellulaire (spécialité Neurosciences) Cellular Biology (specialty Neuroscience), entitled «  Characterization of the deleterous effects of ethanol in Binge drinking like conditions in the adolescent and adult mice. Involvment of PACAP as an endogenous neuroprotective factor ». This Thesis was funded by Inserm and the High Normandy Region (Thesis Supervisors: Dr David VAUDRY et Dr Dominique Duterte-Boucher).

Ms Coralie BRIFAULT (INSERM U982) will defend her thesis (Science) entitled "Impact of targeted and delayed neurodelivery  of the neuropeptide PACAP in a  murine model of cerebral ischemia - The immunomodulation key element in the functional restoration?" on November 20th 2013. (Thesis Supervisors: Drs David VAUDRY and Olivier WURTZ).

Ms Magda HAMZA (INSERM U982) will defend her thesis (Science) entitled "Study of the distribution and role of pleiotrophin during postnatal development of the mice cerebellum" on December 13th 2013. (Thesis Supervisors: Drs Delphine BUREL and David VAUDRY).


On September 13th, 2013,  Dr. Delphine Burel will   present her work entitled “Contribution to the study of the cellular mechanisms involved in the postnatal development of the mouse cerebellum: effects of PACAP and pleiotrophin” to obtain the Habilitation à Diriger des Recherches (HDR). Dr BUREL focuses her research activity on the mechanisms involved in the development of the cerebellar cortex. She is working in the team "Neurotrophic Factors and Neuronal Differentiation" of   Inserm Unit 982.








 A. Lamine, M. Létourneau, N.D. Doan, J. Maucotel, A. Couvineau, H. Vaudry, D. Chatenet, D. Vaudry, A. Fournier. Characterizations of a synthetic pituitary adenylate cyclase-activating polypeptide analog displaying potent neuroprotective activity and reduced in vivo cardiovascular side effects in a Parkinson's disease model. In this article published in Neuropharmacology (2015,  doi:10.1016/j.neuropharm.2015.05.014), researchers of the INRS-Institut Armand-Frappier (Laval, Quebec) in collaboration with their colleagues from INSERM Unit 982 (Rouen University) developed an analog of PACAP which exhibits identical neuroprotective properties than the native peptide but has fewer side effects on the cardiovascular system. This compound therefore appears as an attractive molecular basis to develop PACAP derived medicinal products for the treatment of neurodegenerative diseases.


H. Lacaille H, D. Duterte-Boucher,  D. Liot, H. Vaudry, M. Naassila, D Vaudry. Comparison of the deleterious effects of binge drinking-like alcohol exposure in adolescent and adult mice. In this article published in J. Neurochem. (2014 Dec 31. doi: 10.1111/jnc.13020), Unit 982 Inserm researchers show that massive consumption of alcohol in a 'binge drinking' like manner, causes more damage in the brains of adolescent mice than in adult mice. The study of the mechanisms of action indicates that, unlike adults, in adolescent mice, some genes associated with the repair of DNA damage are under-expressed within few hours following alcohol intake. It was also observed in these adolescent mice exposed to alcohol a lower production of new cells in the brain and memory deficits. This study was the subject of a press release on the website of INSERM.


C. Brifault, M. Gras, D. Liot, V. May, D. Vaudry, O. Wurtz.Delayed pituitary adenylate cyclase-activating polypeptide delivery after brain stroke improves functional recovery by inducing M2 microglia/macrophage polarization. In this article published in Stroke (46:520-528, 2015), researchers from Inserm unit 982 show in a mouse model of cerebral ischemia that a target delivery of the neuropeptide PACAP even 3 days after the onset of infarction effectively reduces post-ischemic functional impairments observed in rodents. This improvement in functional restoration correlates closely with a modulation of the local inflammatory response and more specifically a shift in microglial response towards a neuroprotective M2 phenotype, promoting tissue repair mechanisms. Thus, these studies suggest that immunomodulatory strategies that redirect microglial responses to their neuroprotective M2 phenotype could represent credible therapeutic alternatives for the benefit of stroke patients in an extended therapeutic window. This study has been highlighled in the INSERM Santé Magazine of March-April 2015 (number 24, page 11)


C. Neveu, F. Dulin, B. Lefranc, L. Galas, C. Calbrix, R. Bureau, S. Rault, J. Chuquet, J.A. Boutin. L. Guilhaudis, I. Ségalas-Milazzo, D. Vaudry, H. Vaudry, J. Sopkova-de Oliveira Santos, J. Leprince. Molecular basis of agonist docking in a human GPR103 homology model by site-directed mutagenesis and structure-activity relationship studies. In this paper published in the British Journal of Pharmacology (2014; 171:4425-4439), researchers from Rouen (Inserm Unit 982, PRIMACEN and IRCOF), Caen (CERMN) and the SERVIER Laboratories have by homology a model of the human GPR103 in which the biological active fragment of its natural ligand, the anorexigenic neuropeptide 26RFa was docked. The most stable intermolecular interaction was predicted by 3D molecular modeling and then confirmed experimentally by site-directed mutagenesis. Thsi study led to the design of the first GPR103 antagonist, the LV-2185. This study could be a first step for the development of molecules regulating food intake.


T. Seaborn, A. Ravni, R. Au, B.K. Chow, A. Fournier, O. Wurtz, H. Vaudry, L.E. Eiden, D. Vaudry. Induction of serpine b1a by PACAP or NGF is required for PC12 cells survival after serum withdrawal.

In this article published in the Journal of Neurochemistry (2014; doi: 10.1111/jnc.12780), researchers of INSERM U982, in collaboration with teams in Bathesda, Hong Kong and Montreal, showed that serine peptidase inhibitor, clade B, member 1a (serpine b1a), one of the most induced genes by PACAP in PC12 cells, is necessary for the inhibition of caspase-3 by PACAP and thus participates in its antiapoptotic effect.

D. Burel, J.H. Li, J.L. Do-Rego, A.F. Wang, V. Luu-The, G. Pelletier, Y. Tillet, C. Taragnat, H.B. Kwon, J.Y. Seong, H. Vaudry. Gonadotropin-releasing hormone stimulates the biosynthesis of pregnenolone sulfate and dehydroepiandrosterone sulfate in the hypothalamus.In this article published in Endocrinology (2013, 154:2114-2128), researchers from Inserm U982, in  collaboration with teams from INRA Nouzilly, Laval  University in Quebec and Seoul University in Koreal, show that GnRH controls the biosynthesis of Δ5PS and DHEAS in the frog brain. Double immunohistochemical            labelling revealed that GnRH endings contact neurons, thus expressing hydroxysteroide-sulfotransferase enzyme (HST), responsible for the production of neurosteroid-sulfates. A strong density of GnRHR1 and GnRHR3 receptors is present in the hypothalamic nuclei where HST neurons are located. Finally, GnRH stimulates in a dose-dependent manner the conversion of tritiated pregnenolone in Δ5PS and DHEAS. These data indicate that GnRH may exert some of its behavioral effects through the regulation of neurosteroids sulfates biosynthesis.