Conferences


"Effets de l'alcoolisation aigüe (binge drinking) sur le cerveau de l'adolescent", par David Vaudry

https://webtv.univ-rouen.fr/permalink/v125844d46008fvtdk3w/

 

RegPep2016

On behalf of the International Regulatory Peptide Society, the Summer Neuropeptide Conferences, the European Neuropeptide Club and the Groupe Français des Peptides et des Protéines, we would like to invite you to participate to RegPep2016 that will be held in Rouen (Normandy, France) from July 12th to 14th, 2016. The venue of RegPep2016 will be the Law Faculty, a beautiful new building located in downtown Rouen, on the bank of the Seine River, within walking distance from the Place du Vieux-Marché (where Joan of Arc was burnt alive in 1431) and the famous Cathedral, painted by Claude Monet.

The scientific program will comprise a Lay-public Lecture, 3 Plenary Lectures, 20 Symposia with 80 State-of-the-Art Lectures, 32 free oral communications selected from the abstracts, 12 communications from young investigators and 2 poster sessions.

Several sessions about the ‘Role of neuropeptides in the progression of tumours of the nervous system’, the ‘Therapeutic potential of the PACAP/VIP neuro-peptide family and related peptides in neurodegenerative and neuropsychiatric diseases’, the ‘Role of peptides in stress-related modulation of visceral pain’, ‘New insights on neuropeptides in obesity and metabolic disorders’, ‘Hypocretins/orexins in arousal, stress, reward and cognition’ and ‘Brain circuits underlying stress perception, response, and adaptation mediated and modulated by neuropeptides’ will contribute to a program which should be of broad in-terest for people working in Neurosciences. 

Sessions will address both basic and clinical issues. Participation of clinicians and private companies is encouraged. Basic research will also be well represented with some sessions addressing for instance evolutionary aspects. Attending RegPep2016, you will be able to learn about the most recent advances on peptides that regulate cell, tissue or organ functions in physiological or pathological conditions. For more information regarding the program, please visit the RegPep2016 website (www.regpep2016.fr).

Besides the scientific program, the social events, included in the registration fee of all participants and accompanying persons, will comprise a get-together party on Tuesday July 12th, a visit of Rouen Impressionist Museum and a Banquet Dinner on Wednesday July 13th, and a visit of Rouen plus a firework display on the Seine River on Thursday July 14th. Travel awards for young investigators (graduate students and postdoctoral fellows) will be available. Satellite meetings will be organized before the RegPep2016 (July 11th) and an optional excursion to Etretat Alabaster coast will be proposed after the meeting (July 15th). We very much hope that you will be able to join us for this major international meeting on bioactive peptides in Rouen in 2016. During this meeting, you will meet old friends and colleagues, and initiate new relationships with others working in fields similar to your own.

 

Registrations are now open on the website with an attractive fee until January 31th, 2016 for early registration. If there is anything that we can do to help you attend the congress, please do not hesitate to contact us directly at This email address is being protected from spambots. You need JavaScript enabled to view it.

 

European Neuropeptide Club

On the occasion of the European Neuropeptide Club’s annual congress which took place in Aberdeen (Scotland) from September 28th to October 1st, 2015, Dr David VAUDRY (Inserm U982) was invited to give a lecture entitled ‘How to improve PACAP efficiency for neuroprotection and neurorepair?’.

 

 

21st meeting of the European Society for Neurochemistry During the 21st meeting of the European Society for Neurochemistry, which took place in Tartu, Estonia, Dr David VAUDRY was invited to give a lecture entitled ‘Characterization of neuropeptides which control cerebellar granule cell survival, migration and différentiation’.

 

 

Final meeting of the PeReNE project

 The final meeting of PERENE project was held in Le Havre January 15th and 16th, 2015. On this occasion, the French and British researchers from the different teams of PERENE network have presented their work on peptide research through oral or posters presentations. Three plenary lectures were also given by Pr Heinrich Dircksen (Stockholm University, Stockholm, Suède) « Bioactive peptide in arthropods », Dr Nathalie Thiriet (INSERM U1084, Poitiers) « Protective and proliferative functions of NPY within the brain »and Dr Angelita   Rebollo (UPMC,  Paris) « Enhanced serum proteolysis resitance of cell-penetrating peptides ». Prizes were awarded at the end of the presentations. A prize for the best oral communication was given to Pierre-Michaël COLY for his presentation entitled « GPCR-Induced chemotactic migration requires mitigation of autophagy: involvement in glial cell invasion ».  Another award for best oral communication was won by Carla DELEPE, Elke HAENSELE, Nawel MELE, Marija MILJAK and Jana SOPKOVA-DE OLIVEIRA SANTOS for their presentation entitled « Cyclic peptide hormones: conformation, dynamics and pharmacophores of urotensin and vasopressin ».  The award for best poster was won by Seyma BAHDOUDI for her presentation entitled « The neuropeptide PACAP and the gliopeptide ODN prevent 6-hydroxydopamine-induced apoptosis of cerebellar granule neurons ».

This meeting was also the opportunity to organize the last Steering Committee of the PeReNE project.



19th GFPP Congress

The program and registration forms for the 19th GFPP congress (French Group for Peptides and Proteins) that will be held in Portbail (Manche, France) from May 17th to 22nd, 2015, are available at the following address: http://www.gfpp.fr.  This meeting will feature 13 invited lectures, 28 oral communications and several poster sessions. Requests for oral presentations and scholarships for students can still be sent to the Scientific Committee via the GFPP website until January 15th, 2015. Registration and abstract submissions can be made until January 30th, 2015.  For more information please contact  Jérôme LEPRINCE ( This email address is being protected from spambots. You need JavaScript enabled to view it. ).         

 Congress « Insights into neural stimulation and brain inflammation in stroke – from recovery mechanisms to targeted therapy 

Dr Olivier WURTZ (Inserm U982) will give a conference entitled « PACAP neuropeptide and brain stroke: Immunomodulation, keypoint of improved functional recovery » during the Congress « Insights into neural stimulation and brain inflammation in stroke – from recovery mechanisms to targeted therapy »  in Manchester (UK), November 12th to 14th, 2014.

 

 

Peptide meeting at the University of Rouen hematic Day on Peptides

  Researchers from the University of Rouen, in partnership with Cosmetic Valley cluster, Technopole CBS and GFPP, will organize a series of lectures on "Peptide delivery for therapeutic and cosmetic applications" at the Maison de l’Université, on the campus of Mont-Saint-Aignan, University of Rouen, on November 26th, 2014. This meeting will bring together international experts including Ijeoma UCHEGBU (Nanomerics) ‘Developing neuropeptide therapeutics-overcoming the blood brain barrier challenge’, Paolo BOTTI (Arisgen) ‘Non invasive administration of peptides’, Michel KHRESTCHATISKY (CNRS & Vect-Horus) ‘Development of peptide vectors for the delivery of drugs and imaging agents to different organs, notably the brain’, Joel RICHARD (Ipsen) ‘Peptide delivery: where do we stand and what does the future hold?’, Karl LINTNER (KAL'Idées) ‘Peptides and skin: ‘eppure penetrato!’ and ROGER NEW (Proxima concepts limited) ‘Peptide formulations for oral delivery’. Two additional oral presentations will be selected from submitted abstracts. Some posters will also be presented at lunch time and some visits of the PRIMACEN and PISSARO platforms will be proposed at the end of the day. Participation to this event is free but registration is mandatory before November 10th, 2014 at the following address: http://primacen.fr/meeting/Peptides. For further information, please contact David VAUDRY ( This email address is being protected from spambots. You need JavaScript enabled to view it. ) or Jerôme LEPRINCE (jerome.leprince@univ-rouen.fr).

 

RegPep2014

During the 20th International Symposium on Regulatory Peptides that took place in Kyoto from September 7 to 10, 2014, Dr. David VAUDRY gave a lecture entitled "Characterization of PACAP neuroprotective effects and approaches for therapeutic applications."  During this conference, David VAUDRY was nominated to the Steering Committe of the International Regulatory Peptide Society (http://www.regpep-society.com). Professor Jens Peter Goetze is now the new chairman of the RegPep society and Professor Schmidt Wolfgang, Editor-in-Chief of Regulatory peptides, has also joined the Steering Committe.

 

17th Annual meeting of the LARC-Neuroscience network

 

 The 17th annual meeting of the LARC-Neuroscience Network will be held on Friday October 25th, 2013, in Rouen. The deadline for registration and submission of abstracts is September 15th, 2013. For more information and to register, please visit the LARC-Neuroscience website at: http://larc-neurosciences.org/registration. To submit an abstract, go to: http://larc-neurosciences.univ-rouen.fr/abstract.

 

 

 

 

Thesis

 

Ms Hélène LACAILLE (INSERM U982) defended on June 18th, 2015, her PhD Thesis in une Thèse de Biologie Cellulaire (spécialité Neurosciences) Cellular Biology (specialty Neuroscience), entitled «  Characterization of the deleterous effects of ethanol in Binge drinking like conditions in the adolescent and adult mice. Involvment of PACAP as an endogenous neuroprotective factor ». This Thesis was funded by Inserm and the High Normandy Region (Thesis Supervisors: Dr David VAUDRY et Dr Dominique Duterte-Boucher).

Ms Coralie BRIFAULT (INSERM U982) will defend her thesis (Science) entitled "Impact of targeted and delayed neurodelivery  of the neuropeptide PACAP in a  murine model of cerebral ischemia - The immunomodulation key element in the functional restoration?" on November 20th 2013. (Thesis Supervisors: Drs David VAUDRY and Olivier WURTZ).

Ms Magda HAMZA (INSERM U982) will defend her thesis (Science) entitled "Study of the distribution and role of pleiotrophin during postnatal development of the mice cerebellum" on December 13th 2013. (Thesis Supervisors: Drs Delphine BUREL and David VAUDRY).

 

On September 13th, 2013,  Dr. Delphine Burel will   present her work entitled “Contribution to the study of the cellular mechanisms involved in the postnatal development of the mouse cerebellum: effects of PACAP and pleiotrophin” to obtain the Habilitation à Diriger des Recherches (HDR). Dr BUREL focuses her research activity on the mechanisms involved in the development of the cerebellar cortex. She is working in the team "Neurotrophic Factors and Neuronal Differentiation" of   Inserm Unit 982.

 

 

 

 

 

 

Publications

 A. Lamine, M. Létourneau, N.D. Doan, J. Maucotel, A. Couvineau, H. Vaudry, D. Chatenet, D. Vaudry, A. Fournier. Characterizations of a synthetic pituitary adenylate cyclase-activating polypeptide analog displaying potent neuroprotective activity and reduced in vivo cardiovascular side effects in a Parkinson's disease model. In this article published in Neuropharmacology (2015,  doi:10.1016/j.neuropharm.2015.05.014), researchers of the INRS-Institut Armand-Frappier (Laval, Quebec) in collaboration with their colleagues from INSERM Unit 982 (Rouen University) developed an analog of PACAP which exhibits identical neuroprotective properties than the native peptide but has fewer side effects on the cardiovascular system. This compound therefore appears as an attractive molecular basis to develop PACAP derived medicinal products for the treatment of neurodegenerative diseases.

 

H. Lacaille H, D. Duterte-Boucher,  D. Liot, H. Vaudry, M. Naassila, D Vaudry. Comparison of the deleterious effects of binge drinking-like alcohol exposure in adolescent and adult mice. In this article published in J. Neurochem. (2014 Dec 31. doi: 10.1111/jnc.13020), Unit 982 Inserm researchers show that massive consumption of alcohol in a 'binge drinking' like manner, causes more damage in the brains of adolescent mice than in adult mice. The study of the mechanisms of action indicates that, unlike adults, in adolescent mice, some genes associated with the repair of DNA damage are under-expressed within few hours following alcohol intake. It was also observed in these adolescent mice exposed to alcohol a lower production of new cells in the brain and memory deficits. This study was the subject of a press release on the website of INSERM.

 

C. Brifault, M. Gras, D. Liot, V. May, D. Vaudry, O. Wurtz.Delayed pituitary adenylate cyclase-activating polypeptide delivery after brain stroke improves functional recovery by inducing M2 microglia/macrophage polarization. In this article published in Stroke (46:520-528, 2015), researchers from Inserm unit 982 show in a mouse model of cerebral ischemia that a target delivery of the neuropeptide PACAP even 3 days after the onset of infarction effectively reduces post-ischemic functional impairments observed in rodents. This improvement in functional restoration correlates closely with a modulation of the local inflammatory response and more specifically a shift in microglial response towards a neuroprotective M2 phenotype, promoting tissue repair mechanisms. Thus, these studies suggest that immunomodulatory strategies that redirect microglial responses to their neuroprotective M2 phenotype could represent credible therapeutic alternatives for the benefit of stroke patients in an extended therapeutic window. This study has been highlighled in the INSERM Santé Magazine of March-April 2015 (number 24, page 11)

 

C. Neveu, F. Dulin, B. Lefranc, L. Galas, C. Calbrix, R. Bureau, S. Rault, J. Chuquet, J.A. Boutin. L. Guilhaudis, I. Ségalas-Milazzo, D. Vaudry, H. Vaudry, J. Sopkova-de Oliveira Santos, J. Leprince. Molecular basis of agonist docking in a human GPR103 homology model by site-directed mutagenesis and structure-activity relationship studies. In this paper published in the British Journal of Pharmacology (2014; 171:4425-4439), researchers from Rouen (Inserm Unit 982, PRIMACEN and IRCOF), Caen (CERMN) and the SERVIER Laboratories have by homology a model of the human GPR103 in which the biological active fragment of its natural ligand, the anorexigenic neuropeptide 26RFa was docked. The most stable intermolecular interaction was predicted by 3D molecular modeling and then confirmed experimentally by site-directed mutagenesis. Thsi study led to the design of the first GPR103 antagonist, the LV-2185. This study could be a first step for the development of molecules regulating food intake.

 

T. Seaborn, A. Ravni, R. Au, B.K. Chow, A. Fournier, O. Wurtz, H. Vaudry, L.E. Eiden, D. Vaudry. Induction of serpine b1a by PACAP or NGF is required for PC12 cells survival after serum withdrawal.

In this article published in the Journal of Neurochemistry (2014; doi: 10.1111/jnc.12780), researchers of INSERM U982, in collaboration with teams in Bathesda, Hong Kong and Montreal, showed that serine peptidase inhibitor, clade B, member 1a (serpine b1a), one of the most induced genes by PACAP in PC12 cells, is necessary for the inhibition of caspase-3 by PACAP and thus participates in its antiapoptotic effect.

D. Burel, J.H. Li, J.L. Do-Rego, A.F. Wang, V. Luu-The, G. Pelletier, Y. Tillet, C. Taragnat, H.B. Kwon, J.Y. Seong, H. Vaudry. Gonadotropin-releasing hormone stimulates the biosynthesis of pregnenolone sulfate and dehydroepiandrosterone sulfate in the hypothalamus.In this article published in Endocrinology (2013, 154:2114-2128), researchers from Inserm U982, in  collaboration with teams from INRA Nouzilly, Laval  University in Quebec and Seoul University in Koreal, show that GnRH controls the biosynthesis of Δ5PS and DHEAS in the frog brain. Double immunohistochemical            labelling revealed that GnRH endings contact neurons, thus expressing hydroxysteroide-sulfotransferase enzyme (HST), responsible for the production of neurosteroid-sulfates. A strong density of GnRHR1 and GnRHR3 receptors is present in the hypothalamic nuclei where HST neurons are located. Finally, GnRH stimulates in a dose-dependent manner the conversion of tritiated pregnenolone in Δ5PS and DHEAS. These data indicate that GnRH may exert some of its behavioral effects through the regulation of neurosteroids sulfates biosynthesis.

 

 

 

1.     Original publications of articles linked to the research activity of our team

 

- 2010 –

 

ACL1.            Allais, A., Burel, D., Roy, V., Arthaud, S., Galas, L., Isaac, E.R., Desfeux, A., Parent, B., Fournier, A., Chapillon, P., Sherwood, N.M., Vaudry, H. and Gonzalez, B.J.: Balanced effect of PACAP and FasL on granule cell death during cerebellar development: a morphological, functional and behavioural characterization. J. Neurochem. 113:329–340 (2010). PMID: 20050979

ACL2.            Bardou, I., Leprince, J., Chichery, R., Vaudry, H. and Agin, V.: Vasopressin/oxytocin-related peptides influence long-term memory of a passive avoidance task in the cuttlefish, Sepia officinalis. Neurobiol. Learn. Mem. 93:240-247 (2010). PMID: 19857582

ACL3.            Bardou, I., Maubert, E., Leprince, J., Chichery, R., Dallérac, G., Vaudry, H. and Agin, V.: Ontogeny of oxytocin-like immunoreactivity in the cuttlefish, Sepia officinalis, central nervous system. Dev. Neurosci. 32:19-32 (2010). PMID: 19907130

ACL4.            Bruzzone, F., Cervetto, C., Mazzotta, M.-C., Bianchini, P., Ronzitti, E., Leprince, J., Diaspro, A., Maura, G., Vallarino, M., Vaudry, H. and Marcoli, M.: Urotensin II receptor and acetylcholine release from mouse cervical spinal cord nerve terminals. Neuroscience 170:67-77 (2010). PMID: 20620192

ACL5.            Compère, V., Lanfray, D., Castel, H., Morin, F., Leprince, J., Dureuil, B., Vaudry, H., Pelletier, G. and Tonon, M.-C.: Acute food deprivation reduces expression of diazepam-binding inhibitor, the precursor of the anorexigenic octadecaneuropeptide ODN, in mouse glial cells. J. Mol. Endocrinol. 44:295-299 (2010). PMID: 20219854

ACL6.            Dejda, A., Chan, P., Seaborn, T., Coquet, L., Jouenne, T., Fournier, A., Vaudry, H. and Vaudry, D.: Involvement of stathmin 1 in the neurotrophic effects of PACAP in PC12 cells. J. Neurochem. 114:1498‑1510 (2010). PMID: 20569302

ACL7.            Jarry, M., Diallo, M., Lecointre, C., Desrues, L., Tokay, T., Chatenet, D., Leprince, J., Rossi, O., Vaudry, H., Tonon, M.-C., Prézeau, L., Castel, H. and Gandolfo, P.: The vasoactive peptides urotensin II and urotensin II-related peptide regulate astrocyte activity through common and distinct mechanisms: involvement in cell proliferation. Biochem. J. 428:113-124 (2010). PMID: 20192922

ACL8.            Matsuda, K., Kojima, K., Wada, K., Maruyama, K., Leprince, J., Tonon, M.-C., Uchiyama, M. and Vaudry, H.: ODN-induced anorexigenic action is mediated by the MC4R- and subsequently through the CRH receptor-signaling pathways in goldfish. J. Mol. Neurosci. 42:74-79 (2010). PMID: 20306309

ACL9.            Ukena, K., Tachibana, T., Iwakoshi-Ukena, E., Minakata, H., Kawaguchi, R., Osugi, T., Tobari, Y., Leprince, J., Vaudry, H. and Tsutsui, K.: Identification, localisation and function of a novel avian hypothalamic neuropeptide, 26RFa, and its cognate receptor, G protein-coupled receptor-103. Endocrinology 151:2255-2264 (2010). PMID: 20308530

 

 

- 2011 –

 

ACL10.          Botia, B., Jolivel, V., Burel, D., Le Joncour, V., Roy, V., Naassila, M., Bénard, M., Fournier, A., Vaudry, H. and Vaudry, D.: Neuroprotective effects of PACAP against ethanol-induced toxicity in the developing rat cerebellum. Neurotox. Res. 19:423-434 (2011). PMID: 20422475

ACL11.          Chafai, M., Basille, M., Galas, L., Rostène, W., Gressens, P., Vaudry, H., Gonzalez, B.J. and Louiset, E.: Pituitary adenylate cyclase-activating polypeptide and vasoactive intestinal polypeptide promote the genesis of calcium currents in differentiating mouse embryonic stem cells. Neuroscience 199:103115 (2011). PMID: 22001490


ACL12.Dejda, A., Bourgault, S., Doan, N.D., Létourneau, M., Couvineau, A., Vaudry, H., Vaudry, D. and Fournier, A.: Identification by photoaffinity labeling of the extracellular N-terminal domain of PAC1 receptor as the major binding site for PACAP. Biochimie 93:669-677 (2011). PMID: 21185349

ACL13.          Dejda, A., Seaborn, T., Bourgault, S., Touzani, O., Fournier, A., Vaudry, H. and Vaudry, D.: PACAP and a novel stable analog protect rat brain from ischemia: Insight into the mechanisms of action. Peptides 32:1207-1216 (2011). PMID: 21514338

ACL14.          Doan, N.D., Bourgault, S., Dejda, A., Létourneau, M., Detheux, M., Vaudry, D., Vaudry, H., Chatenet, D. and Fournier, A.: Design and in vitro characterization of PAC1/VPAC1-selective agonists with potent neuroprotective effects. Biochem. Pharmacol. 81:552-561 (2011). PMID: 21114961

ACL15.          Hamdi, Y., Masmoudi-Kouki, O., Kaddour, H., Belhadj, F., Gandolfo, P., Vaudry, D., Mokni, M., Leprince, J., Hachem, R., Vaudry, H., Tonon, M.C. and Amri, M.: Protective effect of the octadecaneuropeptide on hydrogen peroxide-induced oxidative stress and cell death in cultured rat astrocytes. J. Neurochem. 118:416-428 (2011). PMID: 21599667

ACL16.          Le Marec, O., Neveu, C., Lefranc, B., Dubessy, C., Boutin, J.A., Do Régo, J.-C., Costentin, J., Tonon, M.‑C., Tena-Sempere, M., Vaudry, H. and Leprince, J.: Structure-activity relationships of a series of analogues of the RFamide-related peptide 26RFa. J. Med. Chem. 54:4808-4814 (2011). PMID: 21623631

ACL17.          Masmoudi-Kouki, O., Douiri, S., Hamdi, Y., Kaddour, H., Bahdoudi, S., Vaudry, D., Basille, M., Leprince, J., Fournier, A., Vaudry, H., Tonon, M.C. and Amri, M.: Pituitary adenylate cyclase-activating polypeptide protects astroglial cells against oxidative stress-induced apoptosis. J. Neurochem. 117:403‑411 (2011). PMID: 21244427

ACL18.          Matsuda, K., Wada, K., Azuma, M., Leprince, J., Tonon, M.-C., Sakashita, A., Maruyama, K., Uchiyama, M. and Vaudry, H.: The octadecaneuropeptide (ODN) exerts anxiogenic-like action in goldfish. Neuroscience 181:100-108 (2011). PMID: 21382452

ACL19.          Raoult, E., Roussel, B.D., Bénard, M., Lefebvre, T., Ravni, A., Ali, C., Vivien, D., Komuro, H., Fournier, A., Vaudry, H., Vaudry, D. and Galas, L.: Pituitary adenylate cyclase-activating polypeptide (PACAP) stimulates the expression and the release of tissue plasminogen activator (tPA) in neuronal cells: involvement of tPA in the neuroprotective effect of PACAP. J. Neurochem. 119:920-931 (2011). PMID:21919910

 

 

- 2012 –

 

ACL20.          Desrues, L., Lefebvre, T., Lecointre, C., Schouft, M.-T., Leprince, J., Compère, V., Morin, F., Proust, P., Gandolfo, P., Tonon, M.-C. and Castel, H.: Down-regulation of GABAA receptor via promiscuity with the vasoactive peptide urotensin II receptor. Potential involvement in astrocyte plasticity. Plos One 7:e36319 (2012). PMID:22563490

ACL21.          Doan, N.D., Létourneau, M., Vaudry, D., Doucet, N., Folch, B., Vaudry, H., Fournier, A. and Chatenet, D.: Design and characterization of novel cell-penetrating peptides from pituitary adenylate cyclase-activating polypeptide. J. Control. Release 163:256-265 (2012). PMID: 22922050

ACL22.          Doan, N.D., Chatenet, D., Létourneau, M., Vaudry, H., Vaudry, D. and Fournier, A.: Receptor-independent cellular uptake of pituitary adenylate cyclase-activating polypeptide. Biochim. Biophys. Acta 1823:940-949 (2012). PMID: 22343001

ACL23.          Fahrion, J.K., Komuro, Y., Li, Y., Ohno, N., Littner, Y., Raoult, E., Galas, L., Vaudry, D. and Komuro, H.: Rescue of neuronal migration deficits in a mouse model of fetal Minamata disease by increasing neuronal Ca2+ spike frequency. Proc. Natl. Acad. Sci. USA 109:5057-5062 (2012). PMID: 22411806

ACL24.          Galusca, B., Jeandel, L., Germain, N., Alexandre, D., Leprince, J., Anouar, Y., Estour, B., Chartrel, N.: Orexigenic neuropeptide 26RFa: new evidence for an adaptative profile of appetite regulation in anorexia nervosa. J. Clin. Endocrinol. Metab. 97:2012-2018 (2012). PMID:22466335


ACL25.          Hamdi, Y., Kaddour, H., Vaudry, D., Douiri, S., Bahdoudi, S., Leprince, J., Castel, H., Vaudry, H., Amri, M., Tonon, M.C. and Masmoudi-Kouki, O.: The stimulatory effect of the octadecaneuropeptide ODN on astroglial antioxidant enzyme systems is mediated through a GPCR. Front. Endocrinol. 3:138 (2012). PMYD: <{p!n style="background: white;">23181054

ACL26.          Hamdi, Y., Kaddour, H., Vaudry, D., Bahdoudi, S., Douiri, S., Leprince, J., Castel, H., Vaudry, H., Tonon, M.C., Amri, M. and Masmoudi-Kouki, O.: The octadecaneuropeptide ODN protects astrocytes against hydrogen peroxide-induced apoptosis via a PKA/MAPK-dependent mechanism. PLoS One 7:e42498 (2012). PMID: 22927932

ACL27.          Li, Y., Komuro, Y., Fahrion, J.K., Hu, T., Ohno, N., Fenner, K.B., Wooton, J., Raoult, E., Galas, L., Vaudry, D. and Komuro, H.: Light stimuli control neuronal migration by altering of insulin-like growth factor 1 (IGF-1) signaling. Proc. Natl. Acad. Sci. USA 109:2630-2635 (2012). PMID: 22308338

ACL28.          Neveu, C., Lefranc, B., Tasseau, O., Do-Rego, J.C., Bourmaud, A., Chan, P., Bauchat, P., Le Marec, O., Chuquet, J., Guilhaudis, L., Boutin, J.A., Ségalas-Milazzo, I., Costentin, J., Vaudry, H., Baudy-Floc'h, M., Vaudry, D. and Leprince, J.: Rational design of a low molecular weight, stable, potent, and long-lasting GPR103 aza-β3-pseudopeptide agonist. J. Med. Chem. 55:7516-7524 (2012). PMID: 22800498

 

 

- 2013 –

 

ACL29.          Alonzeau, J., Alexandre, D., Jeandel, L., Courel, M., Hautot, C., El Yamani, F.Z., Gobet, F., Leprince, J., Magoul, R., Amarti, A., Pfister, C., Yon, L., Anouar, Y. and Chartrel, N.: The neuropeptide 26RFa is expressed in human prostate cancer and stimulates the neuroendocrine differentiation and the migration of androgeno-independent prostate cancer cells. Europ. J. Cancer 49:511-519 (2013). PMID: 22863147

ACL30.          Azuma, M., Wada, K., Leprince, J., Tonon, M., Uchiyama, M., Takahashi, A., Vaudry, H. and Matsuda, K.: The octadecaneuropeptide stimulates somatolactin release from cultured goldfish pituitary cells. J. Neuroendocrinol. 25:312-321 (2013). PMID: 23163696

ACL31.          Basille-Dugay, M., Vaudry, H., Fournier, A., Gonzalez, B. and Vaudry, D.: Activation of PAC1 receptors in rat cerebellar granule cells stimulates both calcium mobilization from intracellular stores and calcium influx through N-type calcium channels. Front. Endocrinol. 4:56 (2013). PMID: 23675369

ACL32.          Basille-Dugay, M., Hamza, M.M., Tassery, C., Parent, B., Raoult, E., Bénard, M., Raisman-Vozari, R., Vaudry, D. and Burel, D.C.: Spatio-temporal characterization of the pleiotrophinergic system in mouse cerebellum: evidence for its key role during ontogenesis. Exp. Neurol. 247:537-551 (2013). PMID: 23454176

ACL33.          Burel, D., Li, J.H., Do-Rego, J.L., Wang, A.F., Luu-The, V., Pelletier, G., Tillet, Y., Taragnat, C., Kwon, H.B., Seong, J.Y. and Vaudry, H.: Gonadotropin-releasing hormone stimulates the biosynthesis of pregnenolone sulfate and dehydroepiandrosterone sulfate in the hypothalamus. Endocrinology 154:2114‑2128 (2013). PMID: 23554453

ACL34.          Kaddour, H., Hamdi, Y., Vaudry, D., Basille, M., Desrues, L., Leprince, J., Castel, H., Vaudry, H., Tonon, M.C., Amri, M. and Masmoudi-Kouki, O.: The octadecaneuropeptide ODN prevents 6‑hydroxydopamine-induced apoptosis of cerebellar granule neurons through a PKC-MAPK-dependent pathway. J. Neurochem. 125:620-633 (2013). PMID: 23286644

ACL35.          Lanfray, D., Arthaud, S., Ouellet, J., Compère, V., Do Rego, J.L., Leprince, J., Lefranc, B., Castel, H., Bouchard, C., Monge-Roffarello, B., Richard, D., Pelletier, G., Vaudry, H., Tonon, M.C. and Morin, F.: Gliotransmission and brain blucose sensing: critical role of endozepines. Diabetes 62:801-810 (2013). PMID:23160530

ACL36.          Pierry, C., Couve-Bonnaire, S., Guilhaudis, L., Neveu, C., Marotte, A., Lefranc, B., Cahard, D., Segalas-Milazzo, I., Leprince, J. and Pannecoucke, X.: Fluorinated pseudopeptide analogues of neuropeptide 26RFa: synthesis, biological and structural studies. Chem. Bio. Chem. 14:1620-1633 (2013). PMID: 23940098

- 2014 –

 

ACL37.          Bucharles, C., Bizet, P., Arthaud, S., Arabo, A., Leprince, J., Lefranc, B., Cartier, D., Anouar, Y. and Lihrmann, I.: Concordant localization of functional urotensin II and urotensin II-related peptide binding sites in the rat brain: atypical occurrence close to the fourth ventricle. J. Comp. Neurol. 522:2634-2649 (2014). PMID:24478001

ACL38.          Granata, R., Settanni, F., Trovato, L., Gallo, D., Gesmundo, I., Nano, R., Gallo, M.-P., Bergandi, L., Volante, M., Alloatti, G., Piemonti, L., Leprince, J., Papotti, M., Vaudry, H., Ong, H. and Ghigo, E.: RFamide peptides 43RFa and 26RFa both promote survival of pancreatic β-cells and human pancreatic islets but exert opposite effects on insulin secretion. Diabetes 63:2380-2393 (2014). PMID:24622796

ACL39.          Jolivel, V., Arthaud, S., Botia, B., Portal, C., Delest, B., Clavé, G., Leprince, J., Romieu, A., Renard, P.Y., Touzani, O., Ligeret, H., Noack, P., Massonneau, M., Fournier, A., Vaudry, H. and Vaudry, D.: Biochemical characterization of a caspase-3 far-red fluorescent probe for non-invasive optical imaging of neuronal apoptosis. J. Mol. Neurosci. 54:451-462 (2014). PMID: 24865411

ACL40.          Neveu, C., Dulin, F., Lefranc, B., Galas, L., Calbrix, C., Bureau, R., Rault, S., Chuquet, J., Boutin, J.A., Guilhaudis, L., Ségalas-Milazzo, I., Vaudry, D., Vaudry, H., Santos, J.S. and Leprince, J.: Molecular basis of agonist docking in a human GPR103 homology model by site-directed mutagenesis and structure-activity relationship studies. Br. J. Pharmacol. 171:4425-4439 (2014). PMID: 24913445

ACL41.          Raoult, E., Bénard, M., Komuro, H., Lebon, A., Vivien, D., Fournier, A., Vaudry, H., Vaudry, D. and Galas, L.: Cortical-layer-specific effects of PACAP and tPA on interneuron migration during post-natal development of the cerebellum. J. Neurochem. 130:241-254 (2014). PMID: 24646324

ACL42.          Seaborn, T., Ravni, A., Au, R., Chow, B.K., Fournier, A., Wurtz, O., Vaudry, H., Eiden, L.E. and Vaudry, D.: Induction of Serpinb1a by PACAP or NGF is required for PC12 cells survival after serum withdrawal. J. Neurochem. 131:21-32 (2014). PMID: 24899316

 

 

- 2015 –

 

ACL43.          Bénard, M., Lebon, A., Komuro, H., Vaudry, D. and Galas, L.: Ex vivo imaging of postnatal cerebellar granule cell migration using confocal macroscopy. J. Vis. Exp. 99:e52810 (2015). PMID: 25992599

ACL44.          Brifault, C., Gras, M., Liot, D., May, V., Vaudry, D. and Wurtz, O.: Delayed pituitary adenylate cyclase-activating polypeptide delivery after brain stroke improves functional recovery by inducing m2 microglia/macrophage polarization. Stroke 46:520-528 (2015). PMID: 25550371

ACL45.          Do Rego, J.L., Vaudry, D. and Vaudry, H.: The non-benzodiazepine anxiolytic drug etifoxine causes a rapid, receptor-independent stimulation of neurosteroid biosyntehsis. PloS One 10(3):e0120473 (2015). PMID: 25785994

ACL46.          Gach, K., Belkacemi, O., Lefranc, B., Perlikowski, P., Masson, J., Walet-Balieu, M.L., Do-Rego, J.C., Galas, L., Schapman, D., Lamtahri, R., Tonon, M.C., Vaudry, D., Chuquet, J. and Leprince, J.: Detection, characterization and biological activities of [bisphospho-thr(3,9)]ODN, an endogenous molecular form of ODN released by astrocytes. Neuroscience 290:472-484 (2015). PMID: 25639232

ACL47.          Ghali, W., Vaudry, D., Jouenne, T. and Marzouki, M.N.: Lycium europaeum fruit extract: antiproliferative activity on A549 human lung carcinoma cells and PC12 rat adrenal medulla cancer cells and assessment of its cytotoxicity on cerebellum granule cells. Nutr. Cancer. 67:637-646 (2015). PMID: 25825796

ACL48.          Hamdi, Y., Kaddour, H., Vaudry, D., Leprince, J., Zarrouk, A., Hammami, M., Vaudry, H., Tonon, M.C., Amri, M. and Masmoudi-Kouki, O.: Octadecaneuropeptide ODN prevents hydrogen peroxide-induced oxidative damage of biomolecules in cultured rat astrocytes. Peptides 71:56-65 (2015). PMID: 26143507

ACL49.          Hamza, M., Rey, S., Hilber, P., Arabo, A., Collin, T., Vaudry, D. and Burel, D.: Early disruption of extracellular pleiotrophin concentration alters cerebellar neuronal circuit development and function. Mol. Neurobiol. (2015)In press. PMID: 26399645

ACL50.          Lacaille, H., Duterte-Boucher, D., Liot, D., Vaudry, H., Naassila, M. and Vaudry, D.: Comparison of the deleterious effects of binge drinking-like alcohol exposure in adolescent and adult mice. J. Neurochem. 132:629-641 (2015). PMID: 25556946

ACL51.          Lamine, A., Létourneau, M., Doan, N.D., Maucotel, J., Couvineau, A., Vaudry, H., Chatenet, D., Vaudry, D. and Fournier, A.: Characterizations of a synthetic pituitary adenylate cyclase-activating polypeptide analog displaying potent neuroprotective activity and reduced in vivo cardiovascular side effects in a Parkinson's disease model. Neuropharmacology pii: S0028-3908(15)00195-1 (2015). PMID: 26006268

ACL52.          Ogata, K., Shintani, N., Hayata-Takano, A., Kamo, T., Higashi, S., Seiriki, K., Momosaki, H., Vaudry, D., Vaudry, H., Galas, L., Kasai, A., Nagayasu, K., Nakazawa, T., Hashimoto, R., Ago, Y., Matsuda, T., Baba, A. and Hashimoto, H.: PACAP enhances axon outgrowth in cultured hippocampal neurons to a comparable extent as BDNF. PLoS One 10:e0120526 (2015). PMID: 25807538

ACL53.          Prévost, G., Jeandel, L., Arabo, A., Coëffier, M., Alexandre, D., Picot, M., Gobet, F., Leprince, J., Berrahmoune, H., Dechelotte, P., Malagon, M.M., Bonner, C., Kerr-Conte, J., Lefebvre, H., Anouar, Y. and Chartrel, N.: 26RFa acts as an incretin to regulate glucose homeostasis. Diabetes 64:2805-2816 (2015). PMID: 25858563

ACL54.          Tlili, M., Rouatbi, S., Sriha, B., Ben Rhouma, K., Sakly, M., Vaudry, D., Tebourbi, O.* and Wurtz, O.*: Pituitary adenylate cyclase-activating polypeptide reverses ammonium metavanadate-induced airway hyperresponsiveness in rats. Oxid. Med. Cell. Longev. 2015:787561 (15 pages) (2015). * Last co‑authors. PMID: 26199679

ACL55.          Xu, B., Bergqvist, C.A., Sündström, G., Lundell, I., Vaudry, H., Leprince, J. and Larhammar, D.: Characterization of peptide QRFP (26RFa) and its receptor from amphioxus, Branchiostoma floridae. Gen. Comp. Endocrinol. 210:107-113 (2015). PMID: 25449662

 

 

 

2.     Original publications of articles linked to the activity of team members before their integration to the team (2010-2015 period)

 

- 2010 –

 

ACL56.          Chuquet, J., Quilichini, P., Nimchinsky, E.A. and Buzsáki, G.: Predominant enhancement of glucose uptake in astrocytes versus neurons during activation of the somatosensory cortex. J. Neurosci. 30:15298-15303 (2010). PMID: 21068334

ACL57.          Sughir, A., Lahiani-Skiba, M. and Skiba, M.: Preparation of Tiagabine HCl/2-HPβCD complex Pellets by Extrusion-Spheronization using Glycerol Monostearate as Pellet-aid. Lett. Drug Des. Discov. 7:63-69 (2010).

ACL58.          Sughir, A., Skiba, M., Lameiras, P., Coadou, G., Lahiani-Skiba, M. and Oulyadi, H.: Study of interaction between tiagabine hydrochloride and 2-Hydroxypropyl b-cyclodextrin: investigation of inclusion complex. J. Incl. Phenom Macro. Chem. 68:55-63 (2010).

 

 

- 2011 –

 

ACL59.          Ba, O., Lahiani-Skiba, M., Bouzbouz, S. and Skiba, M.: Synthesis of persubstituted Hhydrophilic and hydrophobic β-cyclodextrin derivatives.J. Incl. Phenom. Macro. Chem. 69:333-337 (2011).

ACL60.          Bounoure, F., Beaudeau, P., Mouly, D., Skiba, M. and Lahiani-Skiba, M.: Syndromic surveillance of acute gastroenteritis based on drug consumption. Epidemiol. Infect.139:1388-1395 (2011). PMID: 21108871

ACL61.          Di Castro, M.A.*, Chuquet, J.*, Liaudet, N., Bhaukaurally, K., Santello, M., Bouvier, D., Tiret, P. and Volterra, A.: Local Ca2+ detection and modulation of synaptic release by astrocytes. Nat. Neurosci. 14:1276-1284 (2011). * First co-authors. PMID: 21909085

ACL62.          Lahiani-Skiba, M., Youm, I., Bounoure, F. and Skiba, M.: Improvement in the water solubility and stability of 4ASA by the use of cyclodextrins. J. Incl. Phenom. Macro. Chem. 69:327-331 (2011).

ACL63.          Lahiani-Skiba, M., Bounoure, F., Fessi, H. and Skiba, M.: Effect of Cyclodextrin on Lonidamine release and in-vitro cytotoxicity. J. Incl. Phenom. Macro. Chem. 69:481-485(2011).

 

 

- 2012 –

 

ACL64.          Boukhris, T., Lahiani- Skiba, M. and Skiba, M.: Novel oral formulation of cyclosporine-spray-dried dispersion using cyclodextrin copolymers. Dig. J. Nanomater. Bios. 7:155-164 (2012).

ACL65.          Boukhris, T., Lahiani- Skiba, M., Bounoure, F. and Skiba, M.: New approach for pre-formulation of an oral cyclosporine. Dig. J. Nanomater. Bios. 7:155-164 (2012).

ACL66.          Hubert-Roux, M., Skiba, M., Sughir, A., Lahiani-Skiba, M., Olivier-Chanu, F., Levacher, V. and Lange, C.: Identification of tiagabine degradation products using liquid chromatography with electrospray ionization multistage mass spectrometry and ultra-performance liquid chromatography/high-resolution mass spectrometry. Rapid Commun. Mass Spectrom. 26:287–296 (2012). PMID 22223315

ACL67.          Youm, I., Lahiani-Skiba, M.and Skiba, M.: Validation of a quantitative determination method of paramino-salicylic acid by high-performance liquid chromatography and its application in rat plasma. inflammatory bowel disease - Advances in pathogenesis and management : ISBN 978-953-307-891-5, Edited by: Sami Karoui, Publisher: InTech, January (2012).

 

 

- 2013 –

 

ACL68.          Bellien, J. and Lahiani-Skiba, M.: La PACES en QCM. Initiation à la Connaissance du Médicament. Editions Ellypses, ISBN: 97827298-8358-4 (2013).

ACL69.          Boukhris, T., Lahiani- Skiba, M., Martin, D. and Skiba, M.: Novel oral formulation of cyclosporine-spray-dried dispersion using cyclodextrin terpolymers. J. Incl. Phenom. Macrocycl. Chem. 75:323-332 (2013).

ACL70.          Skiba, M., Bouchal, F., Bounoure, F., Fessi, H. and Lahiani-Skiba, M.: Pharmacokinetic study of an oral Piroxicam formulation containing differents molar ratios of β-cyclodextrins. J. Incl. Phenom. Macrocycl. Chem. 75:311-314 (2013).

ACL71.          Skiba, M. and Lahiani- Skiba, M.: Novel method for preparation of Cyclodextrin Polymers: Physico-Chemical Characterization and Cytotoxicity. J. Incl. Phenom. Macrocycl. Chem.75:341-349 (2013).

ACL72.          Skiba, M., Lahiani-Skiba, M., Milon, N., Bounoure, F. and Fessi, H.: Preparation and characterization of amorphous solid dispersion of nimesulide in copolymer of cyclodextrin for oral drug delivery. J. Nanosci. Nanotechnol. 13:1-8 (2013).

 

 

- 2014 –

 

ACL73.          Bouchal, F., Skiba, M., Fatmi, S., Chaffai, N. and Lahiani-Skiba, M.: Influence of the preparation method on the dissolution properties of piroxicam-cyclodextrins systems. Lett. Drug Des. Discov. 11:6 (2014).

ACL74.          Debouzy, J.C., Crouzier, D., Bourbon, F., Lahiani-Skiba, M. and Skiba, M.: Interaction study of cyclosporin an amorphous solid dispersion of poly alpha cyclodextrin with model membranes by 1H, 2H, 31P-NMR and Electron Spin Resonance. J. Drug Deliv. Article ID 575719 (2014). PMID 24883210

ACL75.          Skiba, M., Lahiani-Skiba, M., Milon, N., Bounoure, F. and Fessi, H.: Preparation and characterization of amorphous solid dispersions of nimesulide in cyclodextrin copolymers. J. Nanosci. Nanotechnol. 14: 2772-2779 (2014). PMID 24734689

 


 

- 2015 -

 

ACL76.          Bouchal, F., Skiba, M., Chaffai, N., Hallouard, F., Fatmi, S.and Lahiani-Skiba, M.: Fast dissolving sublingual cyclodextrin complex of piroxicam in solid dispersion part I: influence of β-CD and HPβ-CD on the dissolution rate of Piroxicam. Int. J. Pharm. 478:625-32 (2015). PMID: 25522828

ACL77.          Fatmi, S., Bournine, L., Iguer-ouada, M., Lahiani-Skiba, M., Bouchal, F. and Skiba, M.: Amorphous solid dispersion studies of camptothecin–cyclodextrin inclusion complexes in PEG 6000. Acta Pol. Pharm. 72:179-192 (2015). PMID: 25850214

ACL78.          Hallouard, F., Lahiani-Skiba, M. and Skiba, M.: Nanometric carriers or metallic nanoparticles: promising platforms for computed tomography applications. In Encyclopedia of Nanoscience and Nanotechnology. Editor: Hari Singh Nalwa. In American Scientific Publishers (2015).

ACL79.          Lahiani-Skiba, M., Hallouard, F., Mehenni, L., Bounoure, F., Fessi, H. and Skiba, M.: Development and characterization of oral liposomes of vegetal ceramide based amphotericin B having enhanced dry solubility and solubility. Mater. Sci. and Eng. C. Mater. Bio. Appl. 48:145–149 (2015). PMID: 25579907

ACL80.          Moulahcene, L., Skiba, M., Senhadji, O., Milon, N., Benamor, M. and Lahiani-Skiba, M.: Inclusion and removal of pharmaceutical residues from aqueous solution using water-insoluble cyclodextrin polymers. Chem. Eng. Res. Des. 97:145-158 (2015).

ACL81.          Moulahcene, L., Senhadji, O., Skiba, M., Lahiani-Skiba, M., Oughlis-Hammache, F. and Benamor, M.: Cyclodextrin polymers for ibuprofen extraction in aqueous solution: recovery, separation and characterization. Desalin. Water Treat. doi:10.1080/19443994.2015.1048734 (2015).

ACL82.          Pelloux, Y., Costentin, J. and Duterte-Boucher, D.: Differential involvement of anxiety and novelty preference levels on oral ethanol consumption in rats. Psychopharmacology (Berl.) 232:2711-2721 (2015). PMID: 25761842

 

 

 

3.     Original publications of articles linked to our activity on the PRIMACEN (imaging) and PISSARO (proteomics) Platforms

 

- 2010 –

 

ACL83.          Al-Ghaferi, N., Kolodziejek, J., Nowotny, N., Coquet, L., Jouenne, T., Leprince, J., Vaudry, H., King, J.D. and Conlon, J.M.: Antimicrobial peptides from the skin secretions of the South-East Asian frog Hylarana erythraea (Ranidae). Peptides 31:548-554 (2010). PMID: 20015460

ACL84.          Benjdia, A., Subramanian, S., Leprince, J., Vaudry, H., Johnson, M.K. and Berteau, O.: Anaerobic sulfatase-maturating enzyme: a mechanistic link with glycyl radical-activating enzymes? FEBS J. 277:1906-1920 (2010). PMID: 20218986

ACL85.          Condamine, E., Courchay, K., Do Rego, J.C., Leprince, J., Mayer, C., Davoust, D., Costentin, J. and Vaudry, H.: Structural and pharmacological characteristics of chimeric peptides derived from peptide E and β‑endorphin reveal the crucial role of the C-terminal YGGFL and YKKGE motifs in their analgesic properties.  Peptides 31:962-972 (2010). PMID: 20138196

ACL86.          Conlon, J.M., Ahmed, E., Coquet, L., Leprince, J., Jouenne, T., Vaudry, H. and King, J.D.: Primary structures of the skin antimicrobial peptides indicate a close, but not conspecific, phylogenetic relationship between the leopard frogs Lithobates onca and Lithobates yavapaiensis (Ranidae). Comp. Biochem. Physiol. Part C: Toxicol. Pharmacol. 151:313-317 (2010). PMID: 20044030

ACL87.          Conlon, J.M., Al-Ghaferi, N., Ahmed, E., Meetani, M.A., Leprince, J. and Nielsen, P.F.: Orthologs of magainin, PGLa, procaerulein-derived, and proxenopsin-derived peptides from skin secretions of the octoploid frog Xenopus amieti (Pipidae). Peptides 31:989-994 (2010). PMID: 20226221


 

ACL88.          Conlon, J.M., Coquet, L., Jouenne, T., Leprince, J., Vaudry, H. and Iwamuro, S.: Evidence from the primary structures of dermal antimicrobial peptides that Rana tagoi okiensis and Rana tagoi tagoi (Ranidae) are not conspecific subspecies. Toxicon 55:430-435 (2010). PMID: 19799928

ACL89.          Fauquembergue, E., Toutirais, O., Tougeron, D., Drouet, A., Le Gallo, M., Desille, M., Cabillic, F., Thomas de la Pintière, C., Iero, M., Rivoltini, L., Baert-Desurmont, S., Leprince, J., Vaudry, H., Sesboué, R., Frébourg, T., Latouche, J.B. and Catros, V.: HLA-A*0201-restricted CEA-derived peptide CAP1 is not a suitable target for T-cell-based immunotherapy. J. Immunother. 33:402-413 (2010). PMID: 20386466

ACL90.          Laloyaux, X., Fautré, E., Blin, T., Purohit, V., Leprince, J., Jouenne, T., Jonas, A.M. and Glinel, K.: Temperature-responsive polymer brushes switching from bactericidal to cell-repellent. Adv. Mater. 22:5024-5028 (2010). PMID: 20734384

ACL91.          Le Dréau, G., Nicot, A., Bénard, M., Thibout, H., Vaudry, D., Martinerie, C. and Laurent, M.: NOV/CCN3 promotes maturation of cerebellar granule neuron precursors. Mol. Cell. Neurosci. 43:60-71 (2010). PMID: 19286457

ACL92.          Mechkarska, M., Ahmed, E., Coquet, L., Leprince, J., Jouenne, T., Vaudry, H., King, J.D. and Conlon, J.M.: Antimicrobial peptides with therapeutic potential from skin secretions of the Marsabit clawed frog Xenopus borealis (Pipidae). Comp. Biochem. Physiol. Part C: Toxicol. Pharmacol. 152:467‑472 (2010).PMID: 20656059

ACL93.          Nigaud, Y., Cosette, P., Collet, A., Song, P.C., Vaudry, D., Vaudry, H., Junter, G.A. and Jouenne, T.: Biofilm-induced modifications in the proteome of Pseudomonas aeruginosa planktonic cells. Biochim. Biophys. Acta. 1804:957-966 (2010). PMID: 20080211

ACL94.          Thebault, S., Deniel, N., Galland, A., Lecleire, S., Charlionet, R., Coeffler, M., Tron, F., Vaudry, D. and Déchelotte, P.: Human duodenal proteome modulations by glutamine and antioxidants. Proteomics Clin. Appl. 4:325-336 (2010). PMID: 21137053

ACL95.          Zatylny-Gaudin, C., Bernay, B., Zanuttini, B., Leprince, J., Vaudry, H. and Henry, J.: Characterization of a novel LFRFamide neuropeptide in the cephalopod Sepia officinalis. Peptides 31:207-214 (2010). PMID: 19954756

 

 

- 2011 –

 

ACL96.          Blin, T., Purohit, V., Leprince, J., Jouenne, T. and Glinel, K.: Bactericidal microparticles decorated by an antimicrobial peptide for easy desinfection of sensitive aqueous solutions. Biomacromolecules 12:1259-1264 (2011). PMID: 21348525

ACL97.          Conlon, J.M., Mechkarska, M., Ahmed, E., Coquet, L., Jouenne, T., Leprince, J., Vaudry, H., Hayes, M.P. and Padgett-Flohr, G.: Host defense peptides in skin secretions of the Oregon spotted frog Rana pretiosa: implications for species resistance to chytridiomycosis. Dev. Comp. Immunol. 35:644-649 (2011). PMID: 21295070

ACL98.          Conlon, J.M., Mechkarska, M., Ahmed, E., Leprince, J., Vaudry, H., King, J.D. and Takada, K.: Purification and properties of antimicrobial peptides from skin secretions of the Eritrea clawed frog Xenopus clivii (Pipidae). Comp. Biochem. Physiol. 153:350-354 (2011). PMID: 21199684

ACL99.          Conlon, J.M., Mechkarska, M., Coquet, L., Jouenne, T., Leprince, J., Vaudry, H., Kolodziejek, J., Nowotny, N. and King, J.D.: Characterization of antimicrobial peptides in the skin secretions from discrete populations of Lithobates chiricahuenis (Ranidae) from central and southern Arizona. Peptides 32:664-669 (2011). PMID: 21262304

ACL100.        Dhennin-Duthille, I., Gautier, M., Faouzi, M., Guilbert, A., Brevet, M., Vaudry, D., Ahidouch, A., Sevestre, H. and Ouadid-Ahidouch, H.: High expression of transient potential channels in human breast cancer epithelial cells and tissues: correlation with pathological parameters. Cell. Physiol. Biochem. 28:813-822 (2011). PMID: 22178934


 

ACL101.        Goichon, A., Coëffier, M., Claeyssens, S., Lecleire, S., Cailleux, A.F., Bôle-Feysot, C., Chan, P., Donnadieu, N., Lerebours, E., Lavoinne, A., Boyer, O., Vaudry, D. and Dechelotte, P.: Effect of enteral glucose supply on protein synthesis, proteolytic pathways, and proteome in human duodenal mucosa. Am. J. Clin. Nutr. 94:784-794 (2011). PMID: 21795435

ACL102.        Letendre, J., Dupont-Rouzeyrol, M., Hanquet, A.C., Durand, F., Budzinski, H., Chan, P., Vaudry, D. and Rocher, B.: Impact of toxicant exposure on the proteomic response to intertidal condition in Mytilus edulis. Comp. Biochem. Physiol. Part. D: Genomics and Proteomics. 6:357-369 (2011). PMID: 21914563

ACL103.        Mechkarska, M., Ahmed, E., Coquet, L., Leprince, J., Jouenne, T., Vaudry, H., King, J.D. and Conlon, J.M.: Peptidomic analysis of skin secretions demonstrates that the allopatric populations of Xenopus muelleri (Pipidae) are not conspecific. Peptides 32:1502-1508 (2011). PMID: 21664395

ACL104.        Mechkarska, M., Ahmed, E., Coquet, L., Leprince, J., Jouenne, T., Vaudry, H., King, J.D., Takada, K. and Conlon, J.M.: Genome duplication with the Xenoponidae do not increase the multiplicity of antimicrobial peptides in Silurana paratropicalis and Xenopus andrei skin secretions. Comp. Biochem. Physiol. 6:206-212 (2011). PMID: 21498136

ACL105.        Paratore, S., Ciotti, M.T., Basille, M., Vaudry, D., Gentile, A., Parenti, R., Calissano, P. and Cavallaro, S.: Gastric inhibitory polypeptide and its receptor are expressed in the central nervous system and support neuronal survival. Cent. Nerv. Syst. Agents Med. Chem. 11:210-222 (2011). PMID: 21919873

ACL106.        Pasquier, J., Lafont, A.G., Leprince, J., Vaudry, H., Rousseau, K. and Dufour, S.: First evidence for a direct inhibitory effect of kisspeptins on LH expression. Gen. Comp. Endocrinol. 173:216-225 (2011). PMID: 21679713

ACL107.        Servili, A., Le Page, Y., Leprince, J., Caraty, A., Escobar, S., Parhar, I.S., Seong, J.Y., Vaudry, H. and Kah, O.: Organization of two independent kisspeptin systems delivered from evolutionary-ancient kiss genes in the brain of zebrafish. Endocrinology 152:1527-1540 (2011). PMID: 21325050

 

 

- 2012 –

 

ACL108.        Cholez, E., Debuysscher, V., Bourgeais, J., Boudot, C., Leprince, J., Tron, F., Brassart, B., Regnier, A., Bissac, E., Pecnard, E., Gouilleux, F., Lassoued, K. and Gouilleux-Gruart, V.: Evidence for a protective role of the STAT5 transcription factor against oxidative stress in human leukemic pre-B cells. Leukemia 26:2390-2397 (2012). PMID: 22522791

ACL109.        Conlon, J.M., Mechkarska, M., Prajeep, M., Sonnevend, A., Coquet, L., Leprince, J., Jouenne, T., Vaudry, H. and King, J.D.: Host-defense peptides in skin secretions of the tetraploid frog Silurana epitropicalis with potent activity against methicillin-resistant Staphylocuccus aureus (MRSA). Peptides 37:113-119 (2012). PMID: 22800690

ACL110.        Enault, J., Zatylny-Gaudin, C., Bernay, B., Lefranc, B., Leprince, J., Baudy-Floc’h, M. and Henry, J.: A complex set of sex pheromones identified in the cuttlefish Sepia officinalis. PlosOne 7:e46531 (2012). PMID: 23118854

ACL111.        King, J.D., Mechkarska, M., Coquet, L., Leprince, J., Jouenne, T., Vaudry, H., Takada, K. and Conlon, J.M.: Host-defense peptides from skin secretions of the tetraploid frog Xenopus petersii and Xenopus pygmaeus, and the octoploid frog Xenopus lenduensis (Pipidae). Peptides 33:35-43 (2012). PMID: 22123629

ACL112.        Mechkarska, M., Prajeep, M., Coquet, L., Leprince, J., Jouenne, T., Vaudry, H., King, J.D. and Conlon, J.M.: The hymenochirins: a family of host-defense peptides from the Congo dwarf clawed frog Hymenochirus boettgeri (Pipidae). Peptides 35:269-275 (2012). PMID: 22497805

ACL113.        Nguyen, T.T., Folch, B., Létourneau, M., Vaudry, D., Truong, N.H., Doucet, N., Chatenet, D. and Fournier, A.: Cardiotoxin-I: an unexpectedly potent insulinotropic agent. Chembiochem. 13:1805-1812 (2012). PMID: 22807058


 

ACL114.        Park, C.R., Kim, D.K., Cho, E.B., You, D.J., Do Rego, J.L., Vaudry, D., Sun, W., Kim, H., Seong, J.Y. and Hwang J.I.: Spatiotemporal expression and functional implication of CXCL14 in the developing mice cerebellum. Mol. Cells 34:289-293 (2012). PMID: 22843118

ACL115.        Qaiser, F., Wahab, F., Wigar, M.A., Hashim, R., Leprince, J., Vaudry, H., Tena-Sempere, M. and Shahab, M.: Study of the role of novel RF-amide neuropeptides in affecting growth hormone secretion in a representative non-human primate (Macaca mulatta). Endocrine 42:658-663 (2012). PMID: 22527890

ACL116.        Rifflet, A., Gavalda, S., Téné, N., Orivel, J., Leprince, J., Guilhaudis, L., Génin, E., Vétillard, A. and Treilhou, M.: Identification and characterization of a novel antimicrobial peptide from the venom of the ant Tetramorium bicarinatum. Peptides 38:363-370 (2012). PMID: 22960382

ACL117.        Wahab, F., Riaz, T., Khan, L.A., Leprince, J., Vaudry, H., Tena-Sempere, M. and Shahab, M.: Peripheral administration of the human kisspeptin-10 and 26RF-amide inhibits plasma testosterone levels in the adult male broiler breeder birds (Gallus domesticus). Pakistan J. Zool. 44:7-14 (2012).

ACL118.        Wahab, F., Salahuddin, H., Anees, M., Leprince, J., Vaudry, H., Tena-Sempere, M. and Shahab, M.: Study of the effect of 26RF- and 43RF-amides on testosterone and prolactine secretion in the adult male rhesus monkey (Macaca mulatta). Peptides 36:23-28 (2012). PMID: 22531487

 

 

- 2013 –

 

ACL119.        Bertrand, J., Tennoune, N., Marion-Letellier, R., Goichon, A., Chan, P., Mbodji, K., Vaudry, D., Déchelotte, P. and Coëffier, M. Evaluation of ubiquitinated proteins by proteomics reveals the role of the ubiquitin proteasome system in the regulation of Grp75 and Grp78 chaperone proteins during intestinal inflammation. Proteomics. 13:3284-3292 (2013). PMID: 24030972

ACL120.        Chevrier, L., de Brevern, A., Hernandez, E., Leprince, J., Vaudry, H., Guedi, A.-M. and De Roux, N.: PRR repeats in the intracellular domain of KiSS1R are important for its export to cell membrane. Mol. Endocrinol. 27:1004-1014 (2013). PMID: 23608644

ACL121.        Conlon, J.M., Mechkarska, M., Pantic, J.M., Lukic, M.L., Coquet, L., Leprince, J., Nielsen, P.F. and Rinaldi, A.C.: An immunomodulatory peptide related to frenatin 2 from skin secretions of the Tyrrhenian painted frog Discoglossus sardus (Alytidae). Peptides 40:65-71 (2013). PMID: 23262358

ACL122.        Conlon, J.M., Prajeep, M., Mechkarska, M., Coquet, L., Leprince, J., Jouenne, T., Vaudry, H. and King, J.D.: Characterization of the host-defense peptides from skin secretions of Merlin’s clawed frog Pseudhymenochirus merlini: insights into phylogenetic relationships among the Pipidae. Comp. Biochem. Physiol. Part D: Genomics and Proteomics 8:352-357 (2013). PMID: 24212286

ACL123.        Goichon, A., Chan, P., Lecleire, S., Coquard, A., Cailleux, A.F., Walrand, S., Lerebours, E., Vaudry, D., Déchelotte, P. and Coëffier, M.: An enteral leucine supply modulates human duodenal mucosal proteome and decreases the expression of enzymes involved in fatty acid beta-oxidation. J. Proteomics 78:535-544 (2013). PMID: 23142318

ACL124.        Mechkarska, M., Prajeep, M., Leprince, J., Vaudry, H., Meetani, M.A., Evans, B.J. and Conlon, J.M.: A comparison of host-defense peptides in skin secretions of female Xenopus laevis x Xenopus borealis and X. borealis x X. laevis F1 hybrids. Peptides 45:1-8 (2013). PMID: 23624316

ACL125.        Panchout, F., Letendre, J., Bultelle, F., Denier, X., Rocher, B., Chan, P., Vaudry, D. and Durand, F.: Comparison of protein-extraction methods for gills of the shore crab, Carcinus maenas (L.), and application to 2DE. J. Biomol. Tech. 24:218-223 (2013). PMID: 24294114

ACL126.        Plancot, B., Santaella, C., Jaber, R., Kiefer-Meyer, M.-C., Follet-Gueye, M.-L., Leprince, J., Gattin, I., Souc, C., Driouich, A. and Vicré-Gibouin, M.: Deciphering the responses of root border-like cells of Arabidopsis and flax to pathogen-derived elicitors. Plant Physiol. 163:1584-1597 (2013). PMID: 24130195


 

- 2014 –

 

ACL127.        Alexandre, D., Hautot, C., Mehio, M., Jeandel, L., Courel, M., Voisin, T., Couvineau, A., Gobet, F., Leprince, J., Pfister, C., Anouar, Y. and Chartrel, N.: The orexin type 1 receptor is overexpressed in advanced prostate cancer with a neuroendocrine differentiation, and mediates apoptosis. Eur. J. Cancer 50:2126-2133 (2014). PMID: 24910418

ACL128.        Bertrand, J., Goichon, A., Chan, P., Azhar, S., Lecleire, S., Donnadieu, N., Vaudry, D., Cailleux, A.F., Déchelotte, P. and Coëffier, M.: Enteral glutamine infusion modulates ubiquitination of heat shock proteins, Grp-75 and Apg-2, in the human duodenal mucosa. Amino Acids 46:1059-1067 (2014). PMID: 24449167

ACL129.        Conlon, J.M., Kolodziejek, J., Mechkarska, M., Coquet, L., Leprince, J., Jouenne, T., Vaudry, H., Nielsen, P.F., Nowotny, N. and King J.D.:  Host defense peptides from Lithobates forreriHylarana luctuosa, and Hylarana signata (Ranidae): phylogenetic relationships inferred from primary structures of ranatuerin-2 and brevinin-2 peptides. Comp. Biochem. Physiol. Part D: Genomics and Proteomics 9:49‑57 (2014). PMID: 24453457

ACL130.        Conlon, J.M., Mechkarska, M., Kolodziejek, J., Nowotny, N., Coquet, L., Leprince, J., Jouenne, T. and Vaudry, H.: Host-defense peptides from skin secretions of Fraser’s clawed frog Xenopus fraseri (Pipidae): further insight into the evolutionary history of the Xenopodinae. Comp. Biochem. Physiol. Part D: Genomics and Proteomics 12:45-52 (2014). PMID: 25463057

ACL131.        Guillemot, J., Guérin, M., Thouennon, E., Montero, M., Leprince, J., Lefebvre, H., Klein, M., Museran, M., Anouar, Y. and Yon, Y.: Characterization and plasma measurement of the WE-14 peptide in patients with pheochromocytoma. PLos One 9:e88698 (2014). PMID: 24523932

ACL132.        Le Mauff, F., Mercier, G., Chan, P., Burel, C., Vaudry, D., Bardor, M., Vézina, L., Couture, M., Lerouge, P. and Landry, N.: Biochemical composition of haemagglutinin-based influenza virus-like particle vaccine produced by transient expression in tobacco plants. Plant. Biotechnol. J. 13:717-725 (2014). PMID: 25523794

ACL133.        Mechkarska, M., Coquet, L., Leprince, J., Jouenne, T., Vaudry, H., Michalak, P. and Conlon, J.M.: Host-defense peptides from skin secretions of the octoploid frogs Xenopus vestitus and Xenopus wittei (Pipidae): insights into phylogenetic relationships. Comp. Biochem. Physiol. Part D: Genomics and Proteomics 11, 20-28 (2014). PMID: 25086320

ACL134.        Salzano, S., Checconi, P., Hanschmann, E.M., Lillig, C.H., Bowler, L.D., Chan, P., Vaudry, D., Mengozzi, M., Coppo, L., Sacre, S., Atkuri, K.R., Sahaf, B., Herzenberg, L.A., Mullen, L. and Ghezzi, P.: Linkage of inflammation and oxidative stress via release of glutathionylated peroxiredoxin-2, which acts as a danger signal. Proc. Natl. Acad. Sci. USA 111:12157-12162 (2014). PMID: 25097261

ACL135.        Téné, N., Roche-Chatain, V., Rifflet, A., Bonnafé, E., Lefranc, B.Leprince, J. and Treilhou M.: Potent bactericidal effects of bicarinalin against strains of the Enterobacter and Cronobacter genera. Food Control 42:202-206 (2014).

ACL136.        Tennoune, N., Chan, P., Breton, J., Legrand, R., Chabane, Y.N., Akkermann, K., Järv, A., Ouelaa, W., Takagi, K., Ghouzali, I., Francois, M., Lucas, N., Bole-Feysot, C., Pestel-Caron,  M., Do Rego, J.C., Vaudry, D., Harro, J., Dé, E., Déchelotte, P. and Fetissov, S.O.: Bacterial ClpB heat-shock protein, an antigen-mimetic of the anorexigenic peptide α-MSH, at the origin of eating disorders. Transl. Psychiatry 4:e458 (2014). PMID: 25290265

 

 

- 2015 –

 

ACL137.        Bénard, M., Schapman, D., Lebon, A., Monterroso, B., Bellenger, M., Le Foll, F., Pasquier, J., Vaudry, H., Vaudry, D. and Galas L.: Structural and functional analysis of tunneling nanotubes (TnTs) using gCW STED and gconfocal approaches. Biol. Cell. doi: 10.1111/boc.201500004 (2015). PMID: 26094971


 

ACL138.        Bertrand, J., Marion-Letellier, R., Azhar, S., Chan, P., Legrand, R., Goichon, A., Ghouzali, I., Aziz, M., Vaudry, D., Savoye, G., Déchelotte, P. and Coëffier, M.: Glutamine enema regulates colonic ubiquitinated-proteins but not proteasome activities during TNBS-induced colitis leading to increased mitochondrial activity. Proteomics 13:2198-2210 (2015). PMID: 25689466

ACL139.        Conlon, J.M., Mechkarska, M., Coquet, L., Leprince, J., Jouenne, T., Vaudry, H. and Measey, G.J.: Evidence from peptidomic analysis of skin secretions that allopatric populations of Xenopus gilli (Anura: Pipidae) constitute distinct lineage. Peptides 63:118-125 (2015). PMID: 25433327

ACL140.        Conlon, J.M., Mechkarska, M., Kolodziejek, J., Leprince, J., Coquet, L., Jouenne, T., Vaudry, H., Novotny, N. and King, J.D.: Host-defense and trefail factor family peptides in skin secretions of the Mawa clawed frog Xenopus boumbaensis (Pipidae). Peptides early edition (2015). PMID: 25849343

ACL141.        Heyer, E., Lory, P., Leprince, J., Moreau, M., Romieu, A., Guardigli, M., Roda, A. and Ziessel, R.: Highly fluorescent and water-soluble diketopyrrolopyrrole dyes for bioconjugation. Angew. Chem. Int. Ed. Engl. 54:2995-2999 (2015). PMID: 25630532

ACL142.        Goichon, A., Bertrand, J., Chan, P., Lecleire, S., Coquard, A., Cailleux, A.F., Vaudry, D., Déchelotte P. and Coëffier M.: Enteral delivery of proteins enhances the expression of proteins involved in the cytoskeleton and protein biosynthesis in human duodenal mucosa. Am. J. Clin. Nutr. 102:359-367 (2015). PMID: 26109581

ACL143.        Quan, F.B., Dubessy, C., Galant, S., Kenigfest, N.B., Djenoune, L., Leprince, J., Wyart, C., Lihrmann, I. and Tostivint, H.: Comparative distribution and in vitro activities of the urotensin II-related peptides URP1 and URP2 in zebrafish: evidence for their colocalization in spinal cerebrospinal fluid-contacting neurons. PloS One 10:eO119290 (2015). PMID: 25781313

ACL144.        Maby, P., Tougeron, D., Hamieh, M., Mlecnik, B., Kora, H., Bindea, G., Angell, H.K., Fredriksen, T., Elie, N., Fauquembergue, E., Drouet, A., Leprince, J., Benichou, J., Mauillon, J., Le Pessot, F., Sesboüé, R., Tuech, J.J., Sabourin, J.C., Michel, P., Frébourg, T., Galon, J. and Latouche, J.B.: Correlation between density of CD8+ T-cell Infiltrate in microsatellite unstable colorectal cancers and frameshift mutations: a rationale for personalized immunotherapy. Cancer Res. early edition (2015) PMID: 26060019

ACL145.          Mullen, L., Seavill, M., Hammouz, R., Bottazzi, B., Chan, P., Vaudry, D. and Ghezzi, P. Development of 'Redox Arrays' for identifying novel glutathionylated proteins in the secretome. Sci Rep. (2015) In Press PMID: 26416726

ACL146.        Vanegas, G., Leprince, J., Lancien, F., Mimassi, N., Vaudry, H. and Le Mével, J.-C.: Divergent cardio-ventilatory and locomotor effects of centrally and peripherally administered urotensin II and urotensin II-related peptides in the unanesthethized trout. Frontiers Neurosci. 9:142 (10 pages) (2015). PMID: 25954149

ACL147.        Young, C.N., Sinadinos, A., Lefebvre, A., Chan, P., Arkle, S., Vaudry, D. and Gorecki, D.C.: A novel mechanism of autophagic cell death in dystrophic muscle regulated by P2RX7 receptor large-pore formation and HSP90. Autophagy 11:113-130 (2015). PMID: 25700737

 

 

4.     Review publications in peer-reviewed journals

 

ACL148.        Bourgault, S., Chatenet, D., Wurtz, O., Doan, N.D., Leprince, J., Vaudry, H., Fournier, A. and Vaudry, D.: Strategies to convert PACAP from a hypophysiotropic neurohormone into a neuroprotective drug. Curr. Pharm. Des. 17:1002-1024 (2011). PMID: 21524253

ACL149.        Chartrel, N., Alonzeau, J., Alexandre, D., Jeandel, L., Alvear-Perez, R., Leprince, J., Boutin, J., Vaudry, H., Anouar, Y. and Llorens-Cortes C.: The RFamide neuropeptide 26RFa and its role in the control of neuroendocrine functions. Front. Neuroendocrinol. 32:387-397 (2011). PMID: 21530572

ACL150.        Seaborn, T., Masmoudi-Kouli, O., Fournier, A., Vaudry, H. and Vaudry, D.: Protective effects of pituitary adenylate cyclase-activating polypeptide (PACAP) against apoptosis. Curr. Pharm. Des. 17:204-214 (2011). PMID: 21348830

ACL151.        Ukena, K., Vaudry, H., Leprince, J. and Tsutsui, K.: Molecular evolution and functional characterization of the orexigenic peptide 26RFa and its receptor in vertebrates. Cell Tissue Res. 343:475-481 (2011). PMID: 21274569

ACL152.        Vaudry, H., Do Rego, J.L., Burel, D., Luu-The, V., Pelletier, G., Vaudry, D. and Tsutsui, K.: Neurosteroid biosynthesis in the brain of amphibians. Front. Endocrinol. 2: article 79, 9 pages (2011). PMID: 22649387

ACL153.        Harmar, A.J., Fahrenkrug, J., Gozes, I., Laburthe, M., May, V., Pisegna, J.R., Vaudry, D., Vaudry, H., Waschek, J.A. and Said, S.I.: Pharmacology and functions of receptors for vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide. Br. J. Pharmacol. 166:4-17 (2012). PMID: 22289055

ACL154.        Do-Régo, J.-L., Seong, J.Y., Burel, D., Leprince, J., Vaudry, D., Luu-The, V., Tonon, M.-C., Tsutsui, K., Pelletier, G. and Vaudry H.: Regulation of neurosteroid biosynthesis by neurotransmitters and neuropeptides. Front. Endocrinol. 3: article 4, 15 pages (2012). PMID: 22654849

ACL155.        Ukena, K., Tachibana, T., Tobari, Y., Leprince, J., Vaudry, H. and Tsutsui, K.: Identification, localization and function of a novel neuropeptide, 26RFa, and its cognate receptor, GPR103 in the avian hypothalamus. Gen. Comp. Endocrinol. 190:42-46 (2013). PMID: 23548680

ACL156.        Komuro, Y., Galas, L., Lebon, A., Raoult, E., Fahrion, J.K., Tilot, A., Kumada, T., Ohno, N., Vaudry, D. and Komuro, H.: The role of calcium and cyclic nucleotide signaling in cerebellar granule cell migration under normal and pathological conditions. Dev. Neurobiol. 75:369‑387 (2014). PMID: 25066767

ACL157.        Ukena, K., Osugi, T., Leprince, J., Vaudry, H. and Tsutsui, K.: Molecular evolution and function of 26RFa/GPR103. J. Mol. Endocrinol. 52:T119-T131 (2014). PMID: 24532655

ACL158.        Vaudry, H., Leprince, J., Chatenet, D., Fournier, A., Lambert, D.G., Le Mével, J.C., Ohlstein, E.H., Schwertani, A., Tostivint, H. and Vaudry, D.: International Union of Basic and Clinical Pharmacology. XCII. Urotensin II, urotensin II-related peptide, and their receptor: from structure to function. Pharmacol. Rev. 67:214-258 (2015). PMID: 25535277

 

 

5.     Didactic reviews

 

OV1.             Botia, B., Jolivel, V., Burel, D., Lacaille, H., Roy, V., Naassila, M., Bénard, M., Fournier, A., Vaudry, H. and Vaudry, D.: Etude de la capacité du PACAP à bloquer les effets délétères de l’éthanol dans le cervelet de rat au cours du développement. Cahier de l’IREB (2012).

OV2.             Lacaille, H., Calbrix, C., Liot, D., Vaudry, H., Duterte-Boucher, D. and Vaudry, D.: Caractérisation du stress oxydatif  induit par une consommation d’alcool en conditions de Binge drinking. Cahiers de l’IREB (2014).

 

 

 

David VAUDRY, CR1 Inserm (HDR), Coordonnateur équipe 2

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Jérôme LEPRINCE, CR1 Inserm (HDR)

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Delphine BEAUJEAN, Maître de Conférences (HDR)

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Julien CHUQUET, Maître de Conférences

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Dominique DUTERTE-BOUCHER, Maître de Conférences

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Olivier WURTZ, Maître de Conférences

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Magali BASILLE-DUGAY, IR Université

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Paul GIULIANI, IE Inserm (CDD)

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Julie MAUCOTEL, IE Université (CDD)

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Milène TETSI-NOMIGNI, IE Université (CDD)

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Hélène BLANCHON, AI Inserm (CDD)

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Leslie CHEVALIER, CDD Université

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Marjorie GRAS,  Adjoint Techn. - Université

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Roger CUBI, Post-doctorant Inserm

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A. LAMINE, Doctorante – co-tutelle Canada

 

Maria I. ROTH, Post-doctorante  Université

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Hélène LACAILLE, Doctorante – Bourse Inserm-Région

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Rhita LAMTAHRI, Doctorante – CDD Université

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Equipe 2 : Facteurs neurotrophiques et différenciation neuronale

Responsable: Dr David Vaudry, CR1 Inserm 

Dans les pays industrialisés, les AVC représentent la troisième cause de mortalité après les maladies cardio-vasculaires et le cancer. L'AVC est également la première cause de handicap acquis chez l'adulte. Les principaux troubles neurologiques observés chez les patients ayant subi un ACV résultent de la perte neuronale massive. Aujourd'hui, le seul médicament approuvé pour le traitement des AVC aux États-Unis et en Europe est l'activateur tissulaire recombinant du plasminogène (rtPA, Actilyse) utilisé comme agent thrombolytique. Néanmoins, l'utilisation du rtPA est limitée à une fenêtre de temps de 3 heures suivant l'apparition des symptômes en raison des risques liés à l'hémorragie et la neurotoxicité. Le PACAP (polypeptide activant l'adénylate cyclase) est un peptide de 38 acides aminés qui a permis de réduire fortement le volume de l'infarctus, même lorsqu'il est délivré pendant plusieurs heures après l'ischémie. Toutefois, en raison de sa structure et de sa demi-vie courte, le PACAP ne peut être utilisé à des fins cliniques. Néanmoins, les forts effets neuroprotecteurs du PACAP suggèrent que des composés dérivés présentant une stabilité accrue et une meilleure spécificité pour le récepteur PAC1 pourraient représenter des agents thérapeutiques précieux pour le traitement de l'AVC en combinaison avec le rtPA. Pour tester cette hypothèse, nous développons actuellement des analogues du PACAP, qui seront ensuite caractérisés à la fois in vitro et in vivo. Les médicaments thrombolytiques ne peuvent être administrés qu'au cours des premières heures après l'AVC et leur efficacité reste limitée. Par conséquent, outre le traitement de la phase aiguë, nous allons explorer des thérapies de remplacement cellulaire. Cette approche comprend l'utilisation de cellules souches génétiquement modifiées exprimant le PACAP de façon inductible, ainsi que l'identification de nouveaux facteurs favorisant la neurogenèse de cellules souches endogènes dans le cerveau adulte. Nous étudions si les cellules souches exprimant le PACAP, une fois injectées dans le cerveau des souris soumises à l'ischémie, peuvent se différencier en neurones, réduire l'inflammation et exercer un effet neuroprotecteur paracrine sur les cellules environnantes. Nous allons également étudier si d’autres peptides produits par le cerveau peuvent après une ischémie favoriser la prolifération, la migration, la différenciation ou la survie des CSE ou des cellules souches neuronales endogènes adultes.
Au cours du développement, un déficit d’oxygénation du cerveau ou une exposition à l’alcool peuvent conduire à des dommages tissulaires. Dans ce contexte, nous étudions les altérations au niveau du cervelet et nous analyserons les mécanismes impliqués. Plus précisément, nous allons  rechercher les peptides pouvant réguler la prolifération, la migration, la différenciation et la survie des neurones progéniteurs. Le but ultime du projet est de produire des informations qui permettront d'élaborer de nouvelles stratégies pour le traitement de patients ayant subi un AVC ou souffrant d’altérations neurodéveloppementales.