Gefluc and Crédit Agricole - December 2015

Grant for a Lumascope
(Dr Hélène CASTEL)



IRIB Newsletter - December 2015

Grant from Crédit Agricole and Gefluc for a Lumascope
(Dr Hélène CASTEL) December N°28



 International Conference on Brain Disorders and Therapeutics - August, 24-26 2015 - London, UK

Characterization of a mouse model of subarachnoid hemorrhage. Involvement of the urotensoin II peptide system on vasospasm and neurosensitivemotor deficits
(Dr Hélène CASTEL)   helene-castel-university-of-rouen-france



  Lay-public lecture - April, 2nd 2015 

Université de Toutes les Cultures

             "Quand le cancer et ses traitements plongent                vos pensées dans le brouillard"
(Dr Hélène CASTEL



Inserm  Lettre Nord-Ouest (semaine 02) - January 2015

Grant from la Ligue Contre le Cancer
(Dr Hélène CASTEL)



IRIB Newsletter - February 2015

 Signaling switch of the UII GPCR in glioma



IRIB Newsletter - January 2015

Impact of cancer therapy on SNC in mice
(Dr Martine DUBOIS)



IRIB Newsletter - November 2014

1st price for the best poster communication
(Pierre-Michael COLY)



18th Annual Meeting of the LARC-Neurosciences Networks  - October 2014

1st price for the best poster communication

(Pierre-Mikael COLY)



IRIB Newsletter - October 2014

IInvited conferences - 20th International Symposium
on Regulatory Peptide - Kyoto, Japan
(Dr Hélène CASTEL and Jane Eileen JOUBERT)


Société Française d'Endocrinologie

Newsletter - March 2013




  France 5                                                                                           

Le magazine de la santé


  IRIB Newsletter - December 2015

1st price for the best oral communication
(Pierre-Michael COLY) December N°28




BFM Business - November, 11 2015 

Votre santé m’intéresse : "La chimiothérapie a-t-elle des impacts sur les fonctions cérébrales?"
(Dr Hélène CASTEL)



Launching of the platform Cancer and Cognition - September, 23 2015 -Paris

Cancer and Cognition Platform of the Canceropole Website*
(Pr Florence JOLY and Dr Hélène CASTEL)



IRIB Newsletter - October 2015

Conferences : GPCR meeting of Biochemical Society, Paris, and 6ème congrès d'Angiogenèse, Prato
(Dr Hélène CASTEL) October N°28



International Conference on Antimicrobial Agents and Chemotherapy - August, 4-6 2015 - Valencia, Spain

Anti-VEGF alter cognitive function and the CA1-CA3 hippocampal activity in mice : the first reported "chemofrog" with targeted cancer therapy
(Dr Hélène CASTEL)



 IRIB conference - May 2015


Chemokines receptors in high grade glioma : differential couplage and cross signalling
(Drs Hélène CASTEL and Fabrice MORIN)




  PeReNe Newsletter - September 2014

Are urotensinergic peptide ligands new chemokines?
(Dr Pierre-Olivier GUICHET et al.)

Congress in Seattle  - February 2014
 Hormone and Metabolic Research
Cover - December 2013
Gefluc - 2012                        










Research team website

                  Inserm U982 - DC2N Laboratory                                                                        
                  University of Rouen, IRIB
                  Team " Astrocytes and vascular niche”
                  76821 Mont-Saint-Aignan – France
                  This email address is being protected from spambots. You need JavaScript enabled to view it.

Nationality - French, German


Dr François Hallouard received a PhD from the University of Lyon 1 in 2012. Since 2006, Dr Hallouard is teaching in Pharmacology (University of Strabourg, Lyon, Rennes and Rouen). Dr Hallouard is currently Pharmacist at the CH of Yvetot and member of the team 3 of  the Inserm U982 (team leader Dr Hélène Castel).
Dr Hallouard is author of 1 patent, 2 chapters of books, 20 publications, 1 conference as invited speaker, 1 oral communication and 20 posters.
Current position – Pharmacist (CH Yvetot), U982, Laboratory of Neuronal and Neuroendocrine Communication and Differentiation. DC2N,


2015    DESC in “Radiopharmacie et Radiobiologie”, University of Rouen
2015    School of Design and animal experimentation (Level I), Oniris, Nantes
2007 - 2013    DES in “Pharmacie Hospitalière et des Collectivités”, University of Lyon I
2009 - 2012     PhD Thesis in “Pharmacotechnie”, University of Lyon I
2009     Master in  “Ingénierie pharmaceutique”, University of Strasbourg
2009     Doctor in Pharmacy, University of Strasbourg
2007 - 2008    DIU in “Prise en charge de l’infection par le VIH”, University of Strasbourg


2015    Pharmacist (CH Yvetot)
2014 - 2015    ATER, University of Rouen
2013 - 2014     ATER, University of Rennes
2013    Post-Doctoral position, University Lyon

Prize and Distinctions

Prize Michel DELALANDE of the French National Academia of Pharmacy (2013).


Biopharmacy, Chemistry, Analytical Chemistry, Pharmaceutical Technology, Medical Imaging, Radiopharmacy, Toxicology, Animal experimentation

  •  National collaborations

- Pr F. Joly - Baclesse center (“Cancer and cognition” platform)
- Dr B. Giffard - Inserm U1077, Caen (“Cancer and cognition” platform)
- Pr. J. Honnorat - Inserm U842, Lyon (Gliomer INCA PLBIO network)
- Pr B. Joseph - ICBMS UMR 5246 CNRS, Lyon (Gliomer INCA PLBIO network)
- Dr L. Meijer - CNRS UPMC, Roscoff (Gliomer INCA PLBIO network)
- Dr L. Prézeau - IGF, Montpellier
- Dr M. Chabbert -  UMR 6214 CNRS, Angers, (ANR Blanc Chemotox_ProG)
- Dr I. Milazzo - UMR 6014 CNRS, COBRA, Rouen (ANR Blanc Chemotox_ProG)
- Pr T. Frébourg and Dr J.M. Flaman - U1079 Inserm, Rouen (CNO grant)
- Pr P.Y. Renard and Dr C. Sabot - COBRA, IRCOF, Rouen (CNO program)
- Drs J. Livet and K. Loulier - Institut de la vision, Paris

  • International collaborations

- Pr G. Pelletier - University of Laval, Quebec, Canada (Inserm-FRSQ programs)
- Pr D. Richards - University of Laval, Quebec, Canada
- Pr R. Leduc and Dr E. Marsault - University of Sherbrooke, Quebec, Canada
- Drs A. Edwards and V. Gubala - University of kent, UK (Interreg European program)
- Dr X. Leroy - Actelion Pharmaceuticals, Bale, Switzerland
- Dr G. Winocur – Canada,  and Dr I. Jonhston  - Australia (ICCTF working group)










Call for application-
Assistant Professor-Neurosciences-Rouen Normandie


Assistant Professor in Neurosciences-Neuro-oncology at the Normandie Rouen University

    The University of Rouen Normandie nurtures internationally strong social and economic links in the fields of energies, aeronautics, logistics, transports and mobility, cosmetology and health. It plays a major role in terms of innovation, through learning institutes, clusters and competitive hubs. The Institute for Research and Innovation in Biomedicine (IRIB - FED4220) is a Federative Structure of Research regrouping all the resources of biomedical research in Haute-Normandie with the objective to develop a high-level biomedical research particularly focused on the understanding of disease physiopathology and the development of new diagnostic and therapeutic tools thanks to the complementarities of clinicians, biologists and chemists of the Normandie Rouen University.

Tenure track as Assistant Professor in Neurosciences- Neuro-oncology

Required basic qualifications:
Candidates must have a PhD or equivalent degree at the time of application. French candidates must be qualified in one of the following sections: 65, Biologie cellulaire; 66, Physiologie; 69, Neurosciences.


    The candidate will join the team Astrocyte and Vascular Niche within the UMR1239 INSERM, DC2N, Rouen. The general objective of the project is to tackle the glial tumor-brain interface in an original angle by developing molecular and cellular approaches and animal models, particularly by means of electrophysiological and in vivo brain imaging. The candidate must possess a solid expertise in neurophysiology, cell signaling with skills in electrophysiological techniques and/or dynamic imaging in vivo. The mastery of molecular tools to target brain/tumor cell populations will be a plus. The candidate will have free access to the local platforms and services of imaging, proteomic, genomic of IRIB federation, to the expertise of the team and of the platform Cancer and Cognition, and will benefit from the infrastructures available in the central animal facility of the UFR Sciences and Techniques.


    The Assistant professor will teach in the field of Neurosciences and Animal Physiology, including electrophysiology and cellular and molecular neurobiology. She or he will be involved in teaching and mentoring neurosciences and physiology skills, participate to international education and exchanges with foreign researchers involved in international training, and be associated with the development of innovative teaching tools (Tice, e-Learning, etc.) and continuing education.
    The courses concerned are the "Life Sciences", in particular "Biochemistry, Molecular Biology, Cellular and Physiology", "Sciences for Health" and the Master "Neurosciences" in the "Neuroscience molecular, cellular and integrated" course. Involvement is expected in international thematic schools and new translational training streams.

Host Team:

    The candidate will develop his work in the laboratory of Neuronal and Neuroendocrine Cell Communication and Differentiation (Inserm U1239, Dir. Y. Anouar) whose research is focused on cerebral and neuroendocrine pathologies. The candidate will integrate the "Astrocyte and Vascular Niche" team (Dr. H Castel), whose work focuses on the cellular and pathophysiological mechanisms that control brain tumorigenesis (proliferation, migration, invasion, angiogenesis, resistance to treatment) and impact of cancer and/or cancer therapies on the functions of the central nervous system. The general objective of the team is to understand the determinants of the invasion of the cerebral parenchyma by glial tumor cells and to seek new therapeutic approaches by combining cellular and animal models up to clinical studies.

Contact: Dr Hélène Castel, DR2 Inserm

E-mail: : This email address is being protected from spambots. You need JavaScript enabled to view it.
Tel : 33-2-35-14-66-30
Inserm U1239
Université de Rouen Normandie


 Cancer and Cognition Platform : Ligue Nationale contre le Cancer labelling , 2016 December


Lumascope - 2015 November 26th